Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.37 |
| ▸ | GSK3A | P49840 | 3/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.33 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867095 | 0.77 | DRD1 (0.48) | DRD1 | |
| SCHEMBL5378136 | 0.68 | CA12 (0.40) | GSK3BGSK3ACDK5CDK5R1CCNB2 | |
| SCHEMBL8806288 | 0.68 | NOS3 (0.36) | — | |
| SCHEMBL6479921 | 0.66 | AHR (0.44) | GSK3BGSK3AJAK2PDE3BPDE3A | |
| SCHEMBL2398708 | 0.64 | SRC (0.42) | GSK3BGSK3AJAK2PDE3BPDE3A | |
| SCHEMBL152281 | 0.62 | CCNB2 (0.54) | GSK3BDRD1CDK5CDK5R1CYP3A4 | |
| SCHEMBL29622074 | 0.62 | CCNB2 (0.54) | GSK3BDRD1CDK5CDK5R1CYP3A4 | |
| SCHEMBL5366153 | 0.62 | GRIA1 (0.42) | GSK3BDRD1PDE3BPDE3ACDK5 | |
| SCHEMBL17675082 | 0.61 | POLB (0.35) | DRD1 | |
| SCHEMBL28136098 | 0.61 | GRIA1 (0.38) | GSK3BPDE3BPDE3ACDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992188-B1 | Substituted heterocyclic derivatives | PFIZER, INC. (US) | 2006-01-31 | — | — | US | disclosed |