Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 5/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.30 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867022 | 0.77 | GSK3B (0.37) | DRD1 | |
| SCHEMBL17224574 | 0.71 | DRD1 (0.74) | DRD1 | |
| SCHEMBL8806288 | 0.71 | NOS3 (0.36) | CRHR1GAAMEN1KMT2A | |
| SCHEMBL18510121 | 0.69 | NOTUM (0.42) | DRD1NOTUMPARP10PARP11 | |
| SCHEMBL17224597 | 0.68 | DRD1 (0.52) | DRD1 | |
| SCHEMBL1761215 | 0.67 | UGT2B17 (0.36) | NOTUMGAAPARP10PARP11 | |
| SCHEMBL17224555 | 0.66 | DRD1 (1.00) | DRD1 | |
| SCHEMBL19153130 | 0.63 | UHRF1 (0.41) | DRD1NOTUMGAA | |
| SCHEMBL31702541 | 0.62 | NOTUM (0.42) | DRD1NOTUM | |
| SCHEMBL6703378 | 0.62 | NOTUM (0.52) | DRD1NOTUMPARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6992188-B1 | Substituted heterocyclic derivatives | PFIZER, INC. (US) | 2006-01-31 | — | — | US | disclosed |