Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 8/20 | 0.42 |
| ▸ | IMPDH1 | P20839 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867258 | 0.83 | IMPDH2 (0.60) | IMPDH2IMPDH1 | |
| SCHEMBL5867277 | 0.81 | IMPDH2 (0.44) | IMPDH2IMPDH1KDM4E | |
| SCHEMBL5867257 | 0.81 | IMPDH2 (0.58) | ALDH1A1GAAIMPDH2IMPDH1KDM4E | |
| SCHEMBL5867242 | 0.80 | IMPDH2 (0.49) | KMT2AIMPDH2IMPDH1 | |
| SCHEMBL5867201 | 0.79 | IMPDH2 (0.48) | IMPDH2IMPDH1 | |
| SCHEMBL5867182 | 0.79 | IMPDH2 (0.41) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL5867189 | 0.79 | IMPDH2 (0.48) | IMPDH2IMPDH1 | |
| SCHEMBL5867202 | 0.79 | IMPDH2 (0.48) | ALDH1A1GAAIMPDH2IMPDH1KDM4E | |
| SCHEMBL5867299 | 0.79 | IMPDH2 (0.51) | ALDH1A1GAAIMPDH2IMPDH1KDM4E | |
| SCHEMBL5867280 | 0.79 | IMPDH2 (0.46) | IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060720-B2 | Inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB CO. (US) | 2006-06-13 | — | — | US | disclosed |