Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 17/20 | 0.45 |
| ▸ | IMPDH1 | P20839 | 12/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867270 | 0.92 | IMPDH2 (0.43) | IMPDH2IMPDH1POLB | |
| SCHEMBL5867267 | 0.92 | IMPDH2 (0.43) | IMPDH2IMPDH1POLBTHRB | |
| SCHEMBL5867262 | 0.86 | IMPDH2 (0.57) | IMPDH2IMPDH1 | |
| SCHEMBL5867252 | 0.85 | QPCT (0.46) | IMPDH2IMPDH1POLBNPC1 | |
| SCHEMBL5867310 | 0.85 | IMPDH2 (0.41) | IMPDH2IMPDH1POLBTHRB | |
| SCHEMBL5867263 | 0.85 | IMPDH2 (0.60) | IMPDH2IMPDH1 | |
| SCHEMBL5867301 | 0.83 | IMPDH2 (0.50) | IMPDH2IMPDH1 | |
| SCHEMBL5867205 | 0.83 | IMPDH2 (0.46) | IMPDH2IMPDH1 | |
| SCHEMBL5867244 | 0.83 | IMPDH2 (0.49) | IMPDH2IMPDH1 | |
| SCHEMBL5867204 | 0.82 | IMPDH2 (0.48) | IMPDH2IMPDH1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060720-B2 | Inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB CO. (US) | 2006-06-13 | — | — | US | disclosed |