Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 15/20 | 0.41 |
| ▸ | IMPDH1 | P20839 | 11/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867270 | 0.86 | IMPDH2 (0.43) | IMPDH2IMPDH1POLB | |
| SCHEMBL5867309 | 0.85 | IMPDH2 (0.42) | IMPDH2IMPDH1POLBLMNA | |
| SCHEMBL5867216 | 0.85 | IMPDH2 (0.45) | IMPDH2IMPDH1POLBTHRB | |
| SCHEMBL5867267 | 0.85 | IMPDH2 (0.43) | IMPDH2IMPDH1POLBLMNATHRB | |
| SCHEMBL5867252 | 0.82 | QPCT (0.46) | IMPDH2IMPDH1POLB | |
| SCHEMBL1474061 | 0.81 | IMPDH2 (0.64) | IMPDH2IMPDH1 | |
| SCHEMBL5867262 | 0.80 | IMPDH2 (0.57) | IMPDH2IMPDH1 | |
| SCHEMBL5867263 | 0.79 | IMPDH2 (0.60) | IMPDH2IMPDH1 | |
| SCHEMBL5867301 | 0.78 | IMPDH2 (0.50) | IMPDH2IMPDH1 | |
| SCHEMBL5867205 | 0.78 | IMPDH2 (0.46) | IMPDH2IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060720-B2 | Inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB CO. (US) | 2006-06-13 | — | — | US | disclosed |