Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 5/20 | 0.35 |
| ▸ | CSF1R | P07333 | 3/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.35 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.33 |
| ▸ | PLK4 | O00444 | 2/20 | 0.33 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3537091 | 0.82 | CD274 (0.41) | S1PR1MEN1LMNAKMT2AKDM4E | |
| SCHEMBL3540616 | 0.79 | SMN1; SMN2 (0.39) | S1PR1MEN1LMNAKMT2AKDM4E | |
| SCHEMBL3540435 | 0.79 | CD274 (0.42) | MEN1LMNAKMT2AKDM4EMAPK1 | |
| SCHEMBL4844832 | 0.75 | CD274 (0.42) | MEN1LMNAKMT2AKDM4ECD274 | |
| SCHEMBL4424582 | 0.74 | HTT (0.53) | S1PR1MEN1LMNAKMT2AKDM4E | |
| SCHEMBL6312390 | 0.74 | MCHR1 (0.43) | S1PR1MEN1LMNAKMT2AHTT | |
| SCHEMBL6313158 | 0.69 | SMN1; SMN2 (0.41) | S1PR1MEN1LMNAKMT2AKDM4E | |
| SCHEMBL3542036 | 0.67 | MEN1 (0.39) | MEN1LMNAKMT2AKDM4EMAPK1 | |
| SCHEMBL5642194 | 0.65 | PARP1 (0.37) | S1PR1MEN1KMT2ACD274OPRM1 | |
| SCHEMBL6304885 | 0.65 | CD274 (0.44) | LMNAKDM4EHTTCD274CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |