Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ERN1 | O75460 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867371 | 0.83 | MGLL (0.53) | CA1CA2TSHRERN1KDM4E | |
| SCHEMBL20465744 | 0.80 | ERN1 (0.52) | ALDH1A1ERN1CYP2A6DGAT1 | |
| SCHEMBL19429 | 0.80 | ERN1 (0.52) | ALDH1A1ERN1CYP2A6DGAT1 | |
| SCHEMBL155586 | 0.77 | KDM4E (0.48) | ENPP2CA1CA2ERN1KDM4E | |
| SCHEMBL31559956 | 0.77 | KDM4E (0.48) | ENPP2CA1CA2ERN1KDM4E | |
| SCHEMBL18384417 | 0.77 | KDM4E (0.48) | ENPP2CA1CA2ERN1KDM4E | |
| SCHEMBL155661 | 0.73 | TDP1 (0.61) | LMNASMN1; SMN2KMT2AERN1TDP1 | |
| SCHEMBL5867419 | 0.72 | KDM4E (0.50) | ENPP2CA1CA2TSHRALDH1A1 | |
| SCHEMBL4552823 | 0.71 | TDP1 (0.48) | SMN1; SMN2ALDH1A1ERN1KDM4ETDP1 | |
| SCHEMBL28615862 | 0.71 | TDP1 (0.53) | LMNAKMT2AERN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |