SCHEMBL5867464

SCHEMBL5867464

CCN(CC)CCN(Cc1ccc(-c2ccc(C(F)(F)F)cc2)cc1)C(=O)Cn1cc(C(C)c2cn[nH]c2)c(=O)nc1SCc1ccc(F)cc1.Cc1ccc(S(=O)(=O)O)cc1

nearest known ligand 0.64

Known targets — ChEMBL curated mechanism

ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PLA2G7 Q13093 20/20 0.64
CYP3A4 P08684 13/20 0.64
CYP2D6 P10635 13/20 0.64
CYP1A2 P05177 1/20 0.58
CYP2C9 P11712 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3106244 0.93 PLA2G7 (0.72) PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9
Hydrochloric Acid SCHEMBL5867348 0.93 PLA2G7 (0.71) PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9
Cadaverine Tartrate SCHEMBL5867463 0.90 PLA2G7 (0.67) PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9
Citric Acid SCHEMBL5867324 0.88 PLA2G7 (0.65) PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9
SCHEMBL4415312 0.87 PLA2G7 (0.64) PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9
SCHEMBL4414086 0.87 PLA2G7 (0.64) PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9
Hydrochloric Acid SCHEMBL4417218 0.87 PLA2G7 (0.63) PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9
Hydrochloric Acid SCHEMBL5867351 0.87 PLA2G7 (0.63) PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9
SCHEMBL5867421 0.87 PLA2G7 (0.66) PLA2G7CYP3A4CYP2D6
Hydrochloric Acid SCHEMBL5867425 0.86 PLA2G7 (0.64) PLA2G7CYP3A4CYP2D6CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7115616-B2 Pyrimidinone compounds SMITHKLINE BEECHAM PLC (GB) 2006-10-03 US disclosed
EP-1479671-A1 Pyrimidinone compounds SMITHKLINE BEECHAM PLC (GB) 2004-11-24 EP disclosed