Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 10/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.45 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867724 | 0.97 | CDK2 (0.48) | CDK2CCNA2CCNA1NLRP3HDAC1 | |
| SCHEMBL5867593 | 0.86 | CDK2 (0.65) | CDK2CCNA2CCNA1CCNE1CDK9 | |
| SCHEMBL5867687 | 0.84 | CDK2 (0.49) | CDK2CCNA2CCNA1CCNE1CDK9 | |
| SCHEMBL5867952 | 0.83 | CDK2 (0.48) | CDK2CCNA2CCNA1CCNE1CDK9 | |
| SCHEMBL5867496 | 0.83 | LMNA (0.50) | CDK2CCNA2CCNA1CCNE1CDK5 | |
| SCHEMBL5867749 | 0.82 | CDK2 (0.49) | CDK2CCNA2CCNA1CCNE1CDK9 | |
| SCHEMBL5867860 | 0.82 | CDK2 (0.49) | CDK2CCNA2CCNA1CCNE1CDK9 | |
| SCHEMBL24413610 | 0.81 | CDK2 (0.47) | CDK2CCNA2CCNA1CCNE1CDK9 | |
| SCHEMBL5867926 | 0.81 | CDK2 (0.62) | CDK2CCNA2CCNA1CCNE1CDK9 | |
| SCHEMBL5867835 | 0.80 | CDK2 (0.76) | CDK2CCNA2CCNA1CCNE1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7034049-B1 | 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents | PHARMACIA ITALIA S.P.A. (IT) | 2006-04-25 | — | — | US | disclosed |
| EP-1202733-B1 | 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS | PHARMACIA ITALIA SPA (IT) | 2005-10-05 | — | — | EP | disclosed |