SCHEMBL5867908

SCHEMBL5867908

O=C(Nc1cc(C2CC2)n[nH]1)c1sccc1Cl

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 3/20 0.44
SENP8 Q96LD8 3/20 0.44
SENP7 Q9BQF6 3/20 0.44
SENP6 Q9GZR1 3/20 0.44
F10 P00742 2/20 0.41
GAA P10253 4/20 0.40
ALDH1A1 P00352 2/20 0.39
MAPT P10636 1/20 0.39
AGTR1 P30556 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
PKM P14618 1/20 0.39
KMT2A Q03164 2/20 0.39
CCNA2 P20248 5/20 0.39
CDK2 P24941 5/20 0.39
CCNA1 P78396 5/20 0.39
TLR8 Q9NR97 1/20 0.38
PRSS12 P56730 2/20 0.36
MAPK1 P28482 1/20 0.35
ATM Q13315 1/20 0.35
NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5868009 0.79 CDK2 (0.64) CCNA2CDK2CCNA1
SCHEMBL5867599 0.79 HSD17B10 (0.52) CASP3SENP8SENP7SENP6ALDH1A1
SCHEMBL5867840 0.78 TYK2 (0.46) GAAALDH1A1MAPTKMT2ACCNA2
SCHEMBL5008226 0.78 CASP3 (0.45) CASP3SENP8SENP7SENP6F10
SCHEMBL5867752 0.77 CCNA2 (0.64) MAPTPKMKMT2ACCNA2CDK2
SCHEMBL5867482 0.77 CCNA2 (0.64) GAAMAPTKMT2ACCNA2CDK2
SCHEMBL5867407 0.76 CCNA2 (0.64) MAPTCCNA2CDK2CCNA1NPC1
SCHEMBL5867536 0.76 MEN1 (0.51) ALDH1A1MAPTKMT2ACCNA2CDK2
SCHEMBL5867678 0.75 NPC1 (0.55) CASP3SENP8SENP7SENP6F10
SCHEMBL5867670 0.75 CCNA2 (0.59) MAPTCCNA2CDK2CCNA1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202733-B1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-10-05 EP claimed
EP-1202733-A4 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2003-05-14 EP claimed
JP-2003507329-A 2003-02-25 JP claimed
EP-1202733-A1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS Pharmacia Italia S.p.A. (IT) 2002-05-08 EP claimed
WO-2001012189-A1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA S.P.A. (IT) 2001-02-22 WO claimed
US-7034049-B1 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents PHARMACIA ITALIA S.P.A. (IT) 2006-04-25 US disclosed
EP-1202733-B1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-10-05 EP disclosed
CN-1454091-A Immunostimulatory nucleic acids UNIV IOWA RES FOUND (US) 2003-11-05 CN disclosed
EP-1202733-A4 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2003-05-14 EP disclosed
CN-1373662-A 3(5)-amino-pyrazole derivs., process for their preparation and their use as antitumor agents PHARMACIA & UP JOHN S P A (IT) 2002-10-09 CN disclosed
EP-1202733-A1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS Pharmacia Italia S.p.A. (IT) 2002-05-08 EP disclosed
US-6218418-B1 THERAPY OF CELL PROLIFERATIVE DISORDERS ASSOCIATED WITH AN ALTERED CELL DEPENDENT KINASE ACTIVITY BY ADMINISTERING AMINO PYRAZOLE DERIVATIVE TO MAMMAL PHARMACIA & UPJOHN S.P.A (IT) 2001-04-17 US disclosed
WO-2001012189-A1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA S.P.A. (IT) 2001-02-22 WO disclosed