SCHEMBL5867678

SCHEMBL5867678

O=C(Nc1cc(C2CC2)n[nH]1)c1sc2ccccc2c1Cl

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 13/20 0.55
RAB9A P51151 13/20 0.55
HDAC1 Q13547 1/20 0.54
HDAC8 Q9BY41 1/20 0.54
HDAC6 Q9UBN7 1/20 0.54
SMN1; SMN2 Q16637 10/20 0.53
MAPT P10636 9/20 0.53
KMT2A Q03164 5/20 0.53
KDM4E B2RXH2 3/20 0.53
MEN1 O00255 3/20 0.53
ALDH1A1 P00352 3/20 0.53
LMNA P02545 2/20 0.53
NFKB1 P19838 1/20 0.53
NFKB2 Q00653 1/20 0.53
RELA Q04206 1/20 0.53
CTDSP1 Q9GZU7 1/20 0.53
HPGD P15428 3/20 0.50
TP53 P04637 2/20 0.50
RXFP1 Q9HBX9 1/20 0.50
OGG1 O15527 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5867911 0.81 CCNA2 (0.60) NPC1RAB9AHDAC1HDAC8HDAC6
SCHEMBL5010387 0.81 HDAC1 (0.58) NPC1RAB9AHDAC1HDAC8HDAC6
SCHEMBL5867981 0.77 TMIGD3 (0.64) RAB9AHDAC1HDAC8HDAC6CASP3
SCHEMBL5867670 0.76 CCNA2 (0.59) NPC1RAB9AMAPTTP53
SCHEMBL5867908 0.75 CASP3 (0.44) NPC1RAB9AMAPTKMT2AALDH1A1
SCHEMBL5867482 0.75 CCNA2 (0.64) NPC1RAB9ASMN1; SMN2MAPTKMT2A
SCHEMBL5867402 0.74 MMP3 (0.48) NPC1RAB9AHDAC8KMT2AMEN1
SCHEMBL5867840 0.73 TYK2 (0.46) RAB9ASMN1; SMN2MAPTKMT2AMEN1
SCHEMBL5867747 0.73 RAB9A (0.51) NPC1RAB9AHDAC1HDAC8HDAC6
SCHEMBL5867407 0.72 CCNA2 (0.64) NPC1RAB9AHDAC6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7034049-B1 3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents PHARMACIA ITALIA S.P.A. (IT) 2006-04-25 US disclosed
EP-1202733-B1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2005-10-05 EP disclosed
EP-1202733-A4 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA SPA (IT) 2003-05-14 EP disclosed
EP-1202733-A1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS Pharmacia Italia S.p.A. (IT) 2002-05-08 EP disclosed
US-6218418-B1 THERAPY OF CELL PROLIFERATIVE DISORDERS ASSOCIATED WITH AN ALTERED CELL DEPENDENT KINASE ACTIVITY BY ADMINISTERING AMINO PYRAZOLE DERIVATIVE TO MAMMAL PHARMACIA & UPJOHN S.P.A (IT) 2001-04-17 US disclosed
WO-2001012189-A1 3(5)-AMINO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS PHARMACIA ITALIA S.P.A. (IT) 2001-02-22 WO disclosed