Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 3/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PDE6D | O43924 | 1/20 | 0.32 |
| ▸ | PDE6A | P16499 | 1/20 | 0.32 |
| ▸ | PDE6G | P18545 | 1/20 | 0.32 |
| ▸ | PDE6B | P35913 | 1/20 | 0.32 |
| ▸ | PDE6C | P51160 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2053486 | 0.83 | MAPK14 (0.35) | HSD11B1MAPK14GPR3MEN1KMT2A | |
| SCHEMBL17514650 | 0.83 | HSD11B1 (0.43) | HSD11B1HTR1AHTR7NISCHGRM2 | |
| SCHEMBL17514776 | 0.83 | HSD11B1 (0.43) | HSD11B1HTR1AHTR7NISCHGRM2 | |
| SCHEMBL17514655 | 0.80 | HSD11B1 (0.41) | HSD11B1HTR1AHTR7NISCHGRM2 | |
| SCHEMBL2049820 | 0.79 | PTPN1 (0.38) | HSD11B1GPR3PDE2APDE10A | |
| SCHEMBL6852286 | 0.78 | KMT2A (0.43) | HSD11B1GAAKMT2A | |
| SCHEMBL17515043 | 0.78 | HSD11B1 (0.42) | HSD11B1HTR1AHTR7NISCHGRM2 | |
| SCHEMBL17514715 | 0.76 | HSD11B1 (0.43) | HSD11B1HTR1AHTR7NISCHGRM2 | |
| SCHEMBL17514502 | 0.75 | HSD11B1 (0.40) | HSD11B1HTR1AHTR7NISCHPDE2A | |
| SCHEMBL22115865 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7151097-B2 | Bicyclic pyrazolyl and imidazolyl compounds and uses thereof | PFIZER INC. (US) | 2006-12-19 | — | — | US | claimed |