Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586937 | 1.00 | FFAR4 (0.37) | FFAR4CACNA1GHTR2AGRM2ALDH1A1 | |
| SCHEMBL581333 | 0.96 | CACNA1G (0.38) | CACNA1GHTR2AGRM2ALDH1A1KDM4E | |
| SCHEMBL3085356 | 0.96 | CACNA1G (0.38) | CACNA1GHTR2AGRM2ALDH1A1KDM4E | |
| SCHEMBL581334 | 0.96 | CACNA1G (0.38) | CACNA1GHTR2AGRM2ALDH1A1KDM4E | |
| SCHEMBL582130 | 0.89 | FFAR4 (0.43) | FFAR4CACNA1GHTR2AGRM2ALDH1A1 | |
| SCHEMBL581685 | 0.89 | PKM (0.42) | ALDH1A1KDM4ENPC1MAPTMEN1 | |
| SCHEMBL3080016 | 0.89 | PKM (0.42) | ALDH1A1KDM4ENPC1MAPTMEN1 | |
| SCHEMBL3073261 | 0.89 | PKM (0.42) | ALDH1A1KDM4ENPC1MAPTMEN1 | |
| SCHEMBL582086 | 0.87 | PPARG (0.40) | ALDH1A1KDM4ENPC1GAAMAPT | |
| SCHEMBL3075222 | 0.87 | PPARG (0.40) | ALDH1A1KDM4ENPC1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |