Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.48 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 7/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8249158 | 1.00 | MME (0.53) | MMEPOLBNAALAD2ACECPA1 | |
| SCHEMBL21461809 | 0.84 | HRH1 (0.49) | MMENAALAD2ACE | |
| SCHEMBL16207519 | 0.84 | HRH1 (0.49) | MMENAALAD2ACE | |
| SCHEMBL19100379 | 0.83 | MMP2 (0.52) | NAALAD2ACECA2 | |
| SCHEMBL22657404 | 0.83 | MMP2 (0.52) | NAALAD2ACECA2 | |
| SCHEMBL7750537 | 0.81 | NAALAD2 (0.70) | NAALAD2ALDH1A1 | |
| SCHEMBL10620657 | 0.81 | MME (0.50) | MMEPOLBACECNR2ALDH1A1 | |
| SCHEMBL8255247 | 0.78 | FOLH1 (0.55) | MMENAALAD2CTSK | |
| SCHEMBL8248672 | 0.78 | FOLH1 (0.55) | MMENAALAD2CTSK | |
| SCHEMBL8249122 | 0.78 | FOLH1 (0.55) | MMENAALAD2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |