Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 9/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 9/20 | 0.49 |
| ▸ | ITGAV | P06756 | 9/20 | 0.49 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.49 |
| ▸ | ITGA5 | P08648 | 9/20 | 0.49 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 5/20 | 0.44 |
| ▸ | ACE | P12821 | 4/20 | 0.44 |
| ▸ | MME | P08473 | 2/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | ITGB5 | P18084 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869925 | 1.00 | ITGB3 (0.49) | ITGB3ITGB1ITGAVITGA2BITGA5 | |
| SCHEMBL5869929 | 1.00 | ITGB3 (0.49) | ITGB3ITGB1ITGAVITGA2BITGA5 | |
| SCHEMBL5869538 | 0.84 | MME (0.54) | FOLH1ACE2ACEMMECPA1 | |
| SCHEMBL5869540 | 0.84 | MME (0.54) | FOLH1ACE2ACEMMECPA1 | |
| SCHEMBL5869548 | 0.84 | MME (0.54) | FOLH1ACE2ACEMMECPA1 | |
| SCHEMBL5869347 | 0.83 | ACE2 (0.47) | ITGB3ITGB1ITGAVITGA2BITGA5 | |
| SCHEMBL5869816 | 0.83 | ACE2 (0.47) | ITGB3ITGB1ITGAVITGA2BITGA5 | |
| SCHEMBL5869824 | 0.83 | ACE2 (0.47) | ITGB3ITGB1ITGAVITGA2BITGA5 | |
| SCHEMBL5869386 | 0.81 | MME (0.55) | ITGB1FOLH1ACE2ACEMME | |
| SCHEMBL5869343 | 0.81 | MME (0.55) | ITGB1FOLH1ACE2ACEMME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | claimed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| US-11337909-B2 | Methods for modulating pigmentation by angiotensin-converting enzyme 2 modulation | MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (DE) | 2022-05-24 | — | — | US | disclosed |
| US-20200360258-A1 | METHODS FOR MODULATING PIGMENTATION BY ANGIOTENSIN-CONVERTING ENZYME 2 MODULATION | MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (DE) | 2020-11-19 | — | — | US | disclosed |
| EP-3717077-A1 | METHODS FOR MODULATING PIGMENTATION BY ANGIOTENSIN-CONVERTING ENZYME 2 MODULATION | Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft (DE) | 2020-10-07 | — | — | EP | disclosed |
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | ITGB3 4401/4885ITGB1 4493/4885ITGAV 4297/4885 |
| US-20200360258-A1 | METHODS FOR MODULATING PIGMENTATION BY ANGIOTENSIN-CONVERTING ENZYME 2 MODULATION | ACE, ACE2, TYR | ITGB3 4387/4885ITGB1 4273/4885ITGAV 4163/4885 |
| US-11337909-B2 | Methods for modulating pigmentation by angiotensin-converting enzyme 2 modulation | ACE, ACE2, TYR | ITGB3 4387/4885ITGB1 4273/4885ITGAV 4163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.