Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.50 |
| ▸ | ACE | P12821 | 2/20 | 0.48 |
| ▸ | CTSK | P43235 | 4/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.47 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869736 | 1.00 | FOLH1 (0.51) | FOLH1BACE1ACECTSKCTSL | |
| SCHEMBL5869726 | 1.00 | FOLH1 (0.51) | FOLH1BACE1ACECTSKCTSL | |
| SCHEMBL5870079 | 0.93 | CTSK (0.48) | CTSKCTSLHSD17B10TACR1CAPN1 | |
| SCHEMBL5870083 | 0.93 | CTSK (0.48) | CTSKCTSLHSD17B10TACR1CAPN1 | |
| SCHEMBL5870077 | 0.93 | CTSK (0.48) | CTSKCTSLHSD17B10TACR1CAPN1 | |
| SCHEMBL8248870 | 0.92 | ANPEP (0.55) | FOLH1ACECAPN1 | |
| SCHEMBL5869701 | 0.90 | CTSK (0.52) | ACECTSKCTSLHSD17B10TACR1 | |
| SCHEMBL5869693 | 0.90 | CTSK (0.52) | ACECTSKCTSLHSD17B10TACR1 | |
| SCHEMBL5869698 | 0.90 | CTSK (0.52) | ACECTSKCTSLHSD17B10TACR1 | |
| SCHEMBL5870015 | 0.89 | CTSK (0.47) | CTSKCTSLHSD17B10TACR1CTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | FOLH1 229/4885BACE1 610/4885ACE 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.