Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | FOLH1 | Q04609 | 8/20 | 0.47 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.46 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GRN | P28799 | 1/20 | 0.42 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8255402 | 1.00 | ALDH1A1 (0.52) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL5869797 | 0.89 | PLA2G2A (0.51) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL8248644 | 0.89 | PLA2G2A (0.51) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL10735795 | 0.87 | CHRM1 (0.52) | FOLH1MAPTCHRM1AKR1A1CHRM3 | |
| SCHEMBL5131686 | 0.81 | CHRM1 (0.46) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL5131687 | 0.81 | CHRM1 (0.46) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL16750050 | 0.81 | CHRM1 (0.46) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL5870532 | 0.81 | ALDH1A1 (0.48) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL5869722 | 0.79 | FOLH1 (0.58) | ALDH1A1MEN1LMNAKMT2AFOLH1 | |
| SCHEMBL8248682 | 0.79 | FOLH1 (0.58) | ALDH1A1MEN1LMNAKMT2AFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |