Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 6/20 | 0.45 |
| ▸ | MMP1 | P03956 | 5/20 | 0.45 |
| ▸ | MMP3 | P08254 | 3/20 | 0.44 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.44 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.43 |
| ▸ | GRN | P28799 | 1/20 | 0.43 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8248701 | 1.00 | FOLH1 (0.47) | FOLH1NTSR1MMP9MMP1MMP3 | |
| SCHEMBL5138638 | 0.86 | MAPT (0.41) | FOLH1NTSR1MMP9MMP1MMP3 | |
| SCHEMBL5869744 | 0.84 | FOLH1 (0.55) | FOLH1MMP9MMP1MMP3GRN | |
| SCHEMBL8255247 | 0.84 | FOLH1 (0.55) | FOLH1MMP9MMP1MMP3GRN | |
| SCHEMBL8248672 | 0.84 | FOLH1 (0.55) | FOLH1MMP9MMP1MMP3GRN | |
| SCHEMBL8249122 | 0.84 | FOLH1 (0.55) | FOLH1MMP9MMP1MMP3GRN | |
| SCHEMBL5139244 | 0.81 | MMP9 (0.42) | NTSR1MMP9MMP1MMP3UGT2B7 | |
| SCHEMBL12861495 | 0.81 | CTSS (0.53) | FOLH1 | |
| SCHEMBL17995301 | 0.79 | UGT2B7 (0.50) | MMP9UGT2B7SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8254158 | 0.78 | MME (0.58) | FOLH1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |