Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 2/20 | 0.51 |
| ▸ | MMP9 | P14780 | 2/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP3 | P08254 | 1/20 | 0.50 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.47 |
| ▸ | ACE | P12821 | 3/20 | 0.47 |
| ▸ | MME | P08473 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8255224 | 1.00 | TBXAS1 (0.51) | TBXAS1MMP9MMP8MMP1MMP3 | |
| SCHEMBL13957293 | 0.87 | TBXAS1 (0.55) | TBXAS1MMP9MMP8KDM4EGPR132 | |
| SCHEMBL5869391 | 0.87 | ACE2 (0.52) | TBXAS1ACE2ACEMMEFOLH1 | |
| SCHEMBL5870206 | 0.87 | ACE2 (0.52) | TBXAS1ACE2ACEMMEFOLH1 | |
| SCHEMBL5870202 | 0.87 | ACE2 (0.52) | TBXAS1ACE2ACEMMEFOLH1 | |
| SCHEMBL5870163 | 0.86 | GPR132 (0.64) | GPR132 | |
| SCHEMBL7419505 | 0.86 | GPR132 (0.64) | GPR132 | |
| SCHEMBL5869845 | 0.86 | GPR132 (0.64) | GPR132 | |
| SCHEMBL5869326 | 0.84 | MME (0.62) | MMP9ACE2ACEMMEFOLH1 | |
| SCHEMBL8257978 | 0.84 | MME (0.62) | MMP9ACE2ACEMMEFOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-6632830-B1 | Blood pressure related disease or disorder, cell proliferation disorder, kidney disorder, kinetensin associated disorder, inflammation associated disorder, or an allergic disorder | MILLENNIUM PHARMACEUTICALS, INC. | 2003-10-14 | — | — | US | disclosed |