Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.53 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CLK1 | P49759 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 5/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 5/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870105 | 1.00 | PTPN1 (0.53) | PTPN1CSNK1DDYRK1AFSCN1ALDH1A1 | |
| SCHEMBL5870118 | 1.00 | PTPN1 (0.53) | PTPN1CSNK1DDYRK1AFSCN1ALDH1A1 | |
| SCHEMBL5869593 | 0.88 | DYRK1A (0.55) | PTPN1CSNK1DDYRK1AFSCN1ALDH1A1 | |
| SCHEMBL5869602 | 0.88 | DYRK1A (0.55) | PTPN1CSNK1DDYRK1AFSCN1ALDH1A1 | |
| SCHEMBL5869618 | 0.88 | DYRK1A (0.55) | PTPN1CSNK1DDYRK1AFSCN1ALDH1A1 | |
| SCHEMBL7419251 | 0.82 | CSNK1D (0.49) | PTPN1CSNK1DDYRK1AFSCN1ALDH1A1 | |
| SCHEMBL5870312 | 0.79 | CSNK1D (0.52) | PTPN1CSNK1DDYRK1AALDH1A1NPC1 | |
| SCHEMBL5870318 | 0.79 | CSNK1D (0.52) | PTPN1CSNK1DDYRK1AALDH1A1NPC1 | |
| SCHEMBL5870325 | 0.79 | CSNK1D (0.52) | PTPN1CSNK1DDYRK1AALDH1A1NPC1 | |
| SCHEMBL5869600 | 0.78 | NPC1 (0.61) | CSNK1DDYRK1AALDH1A1NPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | PTPN1 1799/4885CSNK1D 722/4885DYRK1A 3077/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.