Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 8/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 8/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 7/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 7/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ACP1 | P24666 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5869602 | 1.00 | DYRK1A (0.55) | DYRK1AFSCN1NPC1MAPTCLK1 | |
| SCHEMBL5869618 | 1.00 | DYRK1A (0.55) | DYRK1AFSCN1NPC1MAPTCLK1 | |
| SCHEMBL5869749 | 0.89 | RAB9A (0.59) | DYRK1ANPC1MAPTCLK1ALDH1A1 | |
| SCHEMBL5869705 | 0.89 | RAB9A (0.59) | DYRK1ANPC1MAPTCLK1ALDH1A1 | |
| SCHEMBL5869719 | 0.89 | RAB9A (0.59) | DYRK1ANPC1MAPTCLK1ALDH1A1 | |
| SCHEMBL5870118 | 0.88 | PTPN1 (0.53) | DYRK1AFSCN1NPC1MAPTCLK1 | |
| SCHEMBL5870105 | 0.88 | PTPN1 (0.53) | DYRK1AFSCN1NPC1MAPTCLK1 | |
| SCHEMBL5870108 | 0.88 | PTPN1 (0.53) | DYRK1AFSCN1NPC1MAPTCLK1 | |
| SCHEMBL5870526 | 0.88 | PDPK1 (0.55) | DYRK1ANPC1MAPTCLK1ALDH1A1 | |
| SCHEMBL5870315 | 0.88 | PDPK1 (0.55) | DYRK1ANPC1MAPTCLK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045532-B2 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-05-16 | — | — | US | disclosed |
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | MILLENNIUM PHARMACEUTICALS, INC. | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082496-A1 | ACE-2 modulating compounds and methods of use thereof | ACE, ACE2, AGTR2 | DYRK1A 3077/4885FSCN1 4716/4885NPC1 2323/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.