Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gamma-Aminobutyric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 known ✓ | O75899 | 1/20 | 0.52 |
| ▸ | GABBR1 known ✓ | Q9UBS5 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | BLM | P54132 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.52 |
| ▸ | GABRP | O00591 | 1/20 | 0.52 |
| ▸ | GABRD | O14764 | 1/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.52 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gamma-Aminobutyric Acid SCHEMBL28332520 | 0.94 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL28332521 | 0.94 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC8LMNA | |
| Gamma-Aminobutyric Acid SCHEMBL1685715 | 0.94 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL2768668 | 0.94 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL587529 | 0.94 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC8LMNA | |
| Gamma-Aminobutyric Acid SCHEMBL16177043 | 0.94 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL28879139 | 0.94 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC8LMNA | |
| Gamma-Aminobutyric Acid SCHEMBL9283723 | 0.94 | — | — | |
| Gamma-Aminobutyric Acid SCHEMBL377444 | 0.94 | HDAC3 (0.52) | HDAC3HDAC1HDAC2HDAC8LMNA | |
| Gamma-Aminobutyric Acid SCHEMBL377389 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9339481-B2 | Phosphate-binding magnesium salts and uses thereof | CYPRESS PHARMACEUTICALS, INC. (US) | 2016-05-17 | — | — | US | claimed |
| US-20150320795-A1 | COMPOSITIONS AND METHODS COMPRISING POLYETHYLENE GLYCOL AND MAGNESIUM FOR TREATMENT OF NEURONAL INJURY | WARSAW ORTHOPEDIC INC. | 2015-11-12 | — | — | US | claimed |
| EP-2931292-A1 | COMPOSITIONS AND METHODS COMPRISING POLYETHYLENE GLYCOL AND MAGNESIUM FOR TREATMENT OF NEURONAL INJURY | Warsaw Orthopedic, Inc. (US) | 2015-10-21 | — | — | EP | claimed |
| WO-2014093918-A1 | COMPOSITIONS AND METHODS COMPRISING POLYETHYLENE GLYCOL AND MAGNESIUM FOR TREATMENT OF NEURONAL INJURY | WARSAW ORTHOPEDIC, INC. (US) | 2014-06-19 | — | — | WO | claimed |
| EP-2416786-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | Cypress Pharmaceutical, Inc. (US) | 2012-02-15 | — | — | EP | claimed |
| US-20110045063-A2 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICAL, INC. (US) | 2011-02-24 | — | — | US | claimed |
| WO-2010117370-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | claimed |
| US-20090269399-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICAL, INC. (US) | 2009-10-29 | — | — | US | claimed |
| US-20180161365-A1 | Phosphate-Binding Magnesium Salts And Uses Thereof | CURRAX PHARMACEUTICALS LLC | 2018-06-14 | — | — | US | disclosed |
| EP-2931292-B1 | COMPOSITIONS AND METHODS COMPRISING POLYETHYLENE GLYCOL AND MAGNESIUM FOR TREATMENT OF NEURONAL INJURY | WARSAW ORTHOPEDIC INC (US) | 2018-06-13 | — | — | EP | disclosed |
| US-9889157-B2 | Phosphate-binding magnesium salts and uses thereof | CYPRESS PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170202875-A1 | Phosphate-Binding Magnesium Salts And Uses Thereof | WILMINGTON SAVINGS FUND SOCIETY, FSB | 2017-07-20 | — | — | US | disclosed |
| US-9610267-B2 | Phosphate-binding magnesium salts and uses thereof | CYPRESS PHARMACEUTICALS, INC. (US) | 2017-04-04 | — | — | US | disclosed |
| US-20160256420-A1 | Phosphate-Binding Magnesium Salts And Uses Thereof | WILMINGTON SAVINGS FUND SOCIETY, FSB | 2016-09-08 | — | — | US | disclosed |
| US-8236358-B1 | Phosphate-binding magnesium salts and uses thereof | CYPRESS PHARMACEUTICAL, INC. (US) | 2012-08-07 | — | — | US | disclosed |
| US-20120195964-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICAL, INC. (US) | 2012-08-02 | — | — | US | disclosed |
| EP-2416786-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | Cypress Pharmaceutical, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| US-20110045063-A2 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICAL, INC. (US) | 2011-02-24 | — | — | US | disclosed |
| WO-2010117370-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| US-20090269399-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICAL, INC. (US) | 2009-10-29 | — | — | US | disclosed |