Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5870104 | 0.81 | HPGD (0.38) | TSHRPOLBTDP1HTTSMN1; SMN2 | |
| SCHEMBL6295807 | 0.78 | TSHR (0.34) | TSHRPOLBTDP1SMN1; SMN2USP2 | |
| SCHEMBL5870207 | 0.76 | TSHR (0.37) | TSHRPOLBTDP1USP2ALDH1A1 | |
| SCHEMBL4452957 | 0.69 | CTSS (0.54) | TSHRTDP1USP2ALDH1A1GCK | |
| SCHEMBL4449426 | 0.69 | CTSS (0.54) | TSHRTDP1USP2ALDH1A1GCK | |
| SCHEMBL13677286 | 0.69 | CTSS (0.54) | TSHRTDP1USP2ALDH1A1GCK | |
| SCHEMBL13677361 | 0.68 | CTSS (0.49) | TSHRPOLBTDP1ALDH1A1GCK | |
| SCHEMBL4449263 | 0.68 | CTSS (0.49) | TSHRPOLBTDP1ALDH1A1GCK | |
| SCHEMBL13677386 | 0.68 | CTSS (0.49) | TSHRPOLBTDP1ALDH1A1GCK | |
| SCHEMBL4449272 | 0.67 | CTSV (0.33) | TSHRPOLBTDP1USP2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7132449-B2 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPEUTICS LIMITED (GB) | 2006-11-07 | — | — | US | disclosed |
| US-20040127424-A1 | Inhibitors of cruzipain and other cysteine proteases | AMURA THERAPUTICS LIMITED (GB) | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127424-A1 | Inhibitors of cruzipain and other cysteine proteases | CPN1, CTRL, CPA1 | TSHR 3128/4885POLB 2537/4885TDP1 2370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.