Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 4/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 4/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MIF | P14174 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL887606 | 1.00 | — | — | |
| Histamine SCHEMBL584026 | 1.00 | TDP1 (0.44) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL28347218 | 0.98 | TDP1 (0.42) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL27340939 | 0.98 | — | — | |
| Histamine SCHEMBL1668636 | 0.98 | HRH4 (0.42) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL2279 | 0.98 | — | — | |
| Histamine SCHEMBL5447892 | 0.98 | — | — | |
| Histamine SCHEMBL289072 | 0.98 | HRH4 (0.42) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL7444650 | 0.98 | HRH4 (0.42) | TDP1HRH4HRH3TSHRCYP2C9 | |
| Histamine SCHEMBL4760179 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8592 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4643953-A2 | ANTI- GPRC5D ANTIBODIES, BISPECIFIC ANTIGEN BINDING MOLECULES THAT BIND GPRC5D AND CD3, AND USES THEREOF | Janssen Biotech, Inc. (US) | 2025-11-05 | — | — | EP | claimed |
| EP-4623930-A2 | METHODS FOR IDENTIFYING LILRB-BLOCKING ANTIBODIES | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2025-10-01 | — | — | EP | claimed |
| EP-4602049-A1 | SOS1 INHIBITORS | Bayer Aktiengesellschaft (DE) | 2025-08-20 | — | — | EP | claimed |
| EP-4587439-A1 | SULFONE-SUBSTITUTED PYRIDO[3,4-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | Bayer Aktiengesellschaft (DE) | 2025-07-23 | — | — | EP | claimed |
| US-12364682-B2 | Use of tegaserod in preparation of anti-tumor drug | QINGDAO HAIJI BIOMEDICINE CO., LTD. (CN) | 2025-07-22 | — | — | US | claimed |
| EP-3487882-B1 | ANTI- GPRC5D ANTIBODIES, BISPECIFIC ANTIGEN BINDING MOLECULES THAT BIND GPRC5D AND CD3, AND USES THEREOF | JANSSEN BIOTECH INC (US) | 2025-07-16 | — | — | EP | claimed |
| CN-112672760-B | Novel LILRB4 antibodies and uses thereof | 德克萨斯大学体系董事会 | 2025-05-30 | — | — | CN | claimed |
| US-20250154170-A1 | FUSED PYRIMIDINES AS KRAS INHIBITORS | BAYER AKTIENGESELLSCHAFT (DE) | 2025-05-15 | — | — | US | claimed |
| EP-4553085-A1 | ISOLATED ANTIGEN-BINDING PROTEIN AND USE THEREOF | Hangzhou Sumgen Biotech Co., Ltd. (CN) | 2025-05-14 | — | — | EP | claimed |
| CN-119894893-A | Sulfone substituted pyrido [3,4-D ] pyrimidine derivatives for the treatment of cancer | 拜耳公司 | 2025-04-25 | — | — | CN | claimed |
| EP-0525055-A4 | IMPROVED IONTOPHORETIC ADMINISTRATION OF DRUGS | — | 1993-10-06 | — | — | EP | claimed |
| EP-0525055-A1 | IMPROVED IONTOPHORETIC ADMINISTRATION OF DRUGS | GENSIA PHARMACEUTICALS, INC. (US) | 1993-02-03 | — | — | EP | claimed |
| EP-0513361-A1 | METHOD OF ASSAYING ENDOTOXIN | SEIKAGAKU KOGYO KABUSHIKI KAISHA (SEIKAGAKU CORPORATION) (JP) | 1992-11-19 | — | — | EP | claimed |
| EP-0506207-A2 | Pharmaceutical vehicles for reducing transdermal flux | CHEMEX PHARMACEUTICALS, Inc. (US) | 1992-09-30 | — | — | EP | claimed |
| WO-1991016103-A1 | IMPROVED IONTOPHORETIC ADMINISTRATION OF DRUGS | GENSIA PHARMACEUTICALS, INC. (US) | 1991-10-31 | — | — | WO | claimed |
| EP-0385763-A2 | Cosmetic sticks | Richardson-Vicks, Inc. (US) | 1990-09-05 | — | — | EP | claimed |
| US-4919934-A | Cosmetic sticks | RICHARDSON-VICKS INC. (US) | 1990-04-24 | — | — | US | claimed |
| US-4917890-A | CRUSHING, HOMOGENIZING, EXTRACTING TO GIVE ANTHRAQUINONE-FREE GEL | CARRINGTON LABORATORIES, INC. (US) | 1990-04-17 | — | — | US | claimed |
| US-4895727-A | Using water soluble zinc compound | CHEMEX PHARMACEUTICALS, INC. (US) | 1990-01-23 | — | — | US | claimed |
| EP-0328775-A1 | Processes for preparation of aloe products, products produced thereby and compositions thereof | CARRINGTON LABORATORIES, INC. (US) | 1989-08-23 | — | — | EP | claimed |