Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histamine SCHEMBL58710 | 1.00 | TDP1 (0.44) | — | |
| Histamine SCHEMBL584026 | 1.00 | TDP1 (0.44) | — | |
| Histamine SCHEMBL28347218 | 0.98 | TDP1 (0.42) | — | |
| Histamine SCHEMBL27340939 | 0.98 | — | — | |
| Histamine SCHEMBL1668636 | 0.98 | HRH4 (0.42) | — | |
| Histamine SCHEMBL2279 | 0.98 | — | — | |
| Histamine SCHEMBL5447892 | 0.98 | — | — | |
| Histamine SCHEMBL289072 | 0.98 | HRH4 (0.42) | — | |
| Histamine SCHEMBL7444650 | 0.98 | HRH4 (0.42) | — | |
| Histamine SCHEMBL4760179 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 895 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026090557-A1 | SYSTEMS AND METHODS FOR PROCESSING ISM AND MCAS CLINICAL TRIAL DATA | TELIOS PHARMA INC. (US) | 2026-04-30 | — | — | WO | claimed |
| CN-120136790-A | (HA)2AgSbBr8Hybrid perovskite thin film material, and preparation method and application thereof | 重庆邮电大学 | 2025-06-13 | — | — | CN | claimed |
| EP-4554560-A1 | TOPICAL COMPOSITION AND USES THEREOF | Universidade de Coimbra (PT) | 2025-05-21 | — | — | EP | claimed |
| EP-4553085-A1 | ISOLATED ANTIGEN-BINDING PROTEIN AND USE THEREOF | Hangzhou Sumgen Biotech Co., Ltd. (CN) | 2025-05-14 | — | — | EP | claimed |
| CN-114605330-B | Environment-friendly preparation process of decarboxylated carnosine | 济宁环聚医药科技有限公司 | 2024-12-10 | — | — | CN | claimed |
| CN-117752785-A | Histamine human immunoglobulin preparation and its preparing method | 华兰生物工程重庆有限公司 | 2024-03-26 | — | — | CN | claimed |
| WO-2024013711-A1 | TOPICAL COMPOSITION AND USES THEREOF | UNIVERSIDADE DE COIMBRA (PT) | 2024-01-18 | — | — | WO | claimed |
| WO-2024002266-A1 | ISOLATED ANTIGEN-BINDING PROTEIN AND USE THEREOF | 杭州尚健生物技术有限公司 | 2024-01-04 | — | — | WO | claimed |
| CN-116492481-A | Ultra-small particle size 19 F magnetic resonance imaging nano probe and preparation method and application thereof | 北京化工大学 | 2023-07-28 | — | — | CN | claimed |
| CN-114605330-A | Green preparation process of decarboxylated carnosine | 济宁环聚医药科技有限公司 | 2022-06-10 | — | — | CN | claimed |
| US-20020035268-A1 | Synthesis of histamine dihydrochloride | CYTOVIA, INC. | 2002-03-21 | — | — | US | claimed |
| WO-2002022120-A1 | PAIN RELIEVER AND METHOD OF USE | MEDICAL MERCHANDISING, INC. (US) | 2002-03-21 | — | — | WO | claimed |
| EP-1140857-A1 | SYNTHESIS OF HISTAMINE DIHYDROCHLORIDE | Maxim Pharmaceuticals, Inc. (US) | 2001-10-10 | — | — | EP | claimed |
| US-20010011083-A1 | Pain reliever and method of use | MEDICAL MERCHANDISING, INC. | 2001-08-02 | — | — | US | claimed |
| WO-2000039098-A9 | SYNTHESIS OF HISTAMINE DIHYDROCHLORIDE | MAXIM PHARM INC (US) | 2001-05-17 | — | — | WO | claimed |
| US-6197823-B1 | Pain reliever and method of use | MEDICAL MERCHANDISING, INC. | 2001-03-06 | — | — | US | claimed |
| WO-2000039098-A1 | SYNTHESIS OF HISTAMINE DIHYDROCHLORIDE | MAXIM PHARMACEUTICALS, INC. (US) | 2000-07-06 | — | — | WO | claimed |
| US-5043162-A | Mixture of lower alkyl nicotinate and histamine hydrochloride | TRAGER SEYMOUR F (US) | 1991-08-27 | — | — | US | claimed |
| US-4695627-A | PHOSPHORUS PENTACHLORIDE, OLEFIN | GIST-BROCADES N.V. (NL) | 1987-09-22 | — | — | US | claimed |
| US-4250307-A | Process for the preparation of 7-amino-cephalosporanic acid | ROUSSEL UCLAF (FR) | 1981-02-10 | — | — | US | claimed |