Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA5A | P35218 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.35 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8775959 | 0.80 | CYP1A2 (0.48) | TSHRCYP1A2CA1CA2CA5A | |
| SCHEMBL11838595 | 0.78 | ALDH1A1 (0.46) | TSHRCYP1A2CA1CA2CA5A | |
| Chlorotriphenylmethane SCHEMBL16781670 | 0.74 | TSHR (0.65) | TSHRCYP1A2ALDH1A1KCNN4PTPN1 | |
| Chlorotriphenylmethane SCHEMBL461 | 0.74 | TSHR (0.65) | TSHRCYP1A2ALDH1A1KCNN4PTPN1 | |
| SCHEMBL8138277 | 0.72 | CA1 (0.46) | TSHRCYP1A2CA1CA2CA5A | |
| Chlorotriphenylmethane SCHEMBL113884 | 0.71 | TSHR (0.61) | TSHRCYP1A2ALDH1A1KCNN4PTPN1 | |
| Chlorotriphenylmethane SCHEMBL7246540 | 0.71 | TSHR (0.61) | TSHRCYP1A2ALDH1A1KCNN4PTPN1 | |
| Chlorotriphenylmethane SCHEMBL29446246 | 0.71 | TSHR (0.61) | TSHRCYP1A2ALDH1A1KCNN4PTPN1 | |
| Chlorotriphenylmethane SCHEMBL7567317 | 0.71 | TSHR (0.61) | TSHRCYP1A2ALDH1A1KCNN4PTPN1 | |
| Chlorotriphenylmethane SCHEMBL11237663 | 0.71 | TSHR (0.61) | TSHRCYP1A2ALDH1A1KCNN4PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552199-A1 | IMPROVED STABLE AQUEOUS FORMULATION OF (E)-4-CARBOXYSTYRYL-4-CHLOROBENZYL SULFONE | Onconova Therapeutics, Inc. (US) | 2013-02-06 | — | — | EP | disclosed |
| US-7056953-B2 | (E)-styryl sulfone anticancer agents | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2006-06-06 | — | — | US | disclosed |
| US-6762207-B1 | TARGETING RECEPTOR TYROSINE KINASES; SELECTIVE TUMOR CELL APOPTOSIS | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2004-07-13 | — | — | US | disclosed |
| US-6667346-B2 | Administration of a radioprotective alpha, beta unsaturated aryl sulfone compound to a patient prior to anticancer radiotherapy reduces cytotoxic side effects of radiation on normal cells | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-12-23 | — | — | US | disclosed |
| US-6656973-B2 | Anticancer chemotherapy, and cytoprotective agents administered before, during or after chemotherapy to protect the normal cells of the patient | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-12-02 | — | — | US | disclosed |