Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.61 |
| ▸ | DRD1 | P21728 | 5/20 | 0.61 |
| ▸ | HTR2C | P28335 | 5/20 | 0.61 |
| ▸ | HRH1 | P35367 | 5/20 | 0.61 |
| ▸ | HTR2B | P41595 | 5/20 | 0.61 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.61 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 4/20 | 0.51 |
| ▸ | HRH2 | P25021 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871524 | 0.90 | GAA (0.67) | HTR2ADRD1HTR2CHRH1HTR2B | |
| SCHEMBL28742041 | 0.79 | GAA (0.58) | HTR2ADRD1HTR2CHRH1HTR2B | |
| SCHEMBL8279384 | 0.79 | HTR2A (0.62) | HTR2ADRD1HTR2CHRH1HTR2B | |
| SCHEMBL1991377 | 0.79 | HTR2A (0.62) | HTR2ADRD1HTR2CHRH1HTR2B | |
| SCHEMBL5871773 | 0.77 | KCNH2 (0.62) | HTR2ADRD1HTR2CHRH1HTR2B | |
| Volinanserin SCHEMBL30543449 | 0.76 | HTR2B (1.00) | HTR2ADRD1HTR2CHRH1HTR2B | |
| Volinanserin SCHEMBL29356737 | 0.76 | HTR2B (1.00) | HTR2ADRD1HTR2CHRH1HTR2B | |
| SCHEMBL4078621 | 0.76 | HTR2A (1.00) | HTR2ADRD1HTR2CHRH1HTR2B | |
| Volinanserin SCHEMBL340674 | 0.76 | HTR2B (1.00) | HTR2ADRD1HTR2CHRH1HTR2B | |
| Volinanserin SCHEMBL4227186 | 0.76 | HTR2B (1.00) | HTR2ADRD1HTR2CHRH1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7071201-B2 | Serotonin antagonism; muscle relaxant for myotonia; such as 1-(1-(2-(4-methoxyphenyl)ethyl)piperidin-4-yl)-7-methoxy-1,2,3,4 -tetrahydroquinoline | EISAI CO., LTD. (JP) | 2006-07-04 | — | — | US | disclosed |
| EP-0976732-B1 | 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES | EISAI CO LTD (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-6579881-B2 | Indoles | EISAI CO., LTD. (JP) | 2003-06-17 | — | — | US | disclosed |
| US-6448243-B1 | SEROTONIN ANTAGONIST FOR TREATING, AMELIORATING AND PREVENTING SPASTIC PARALYSIS OR CENTRAL MUSCLE RELAXANTS FOR AMELIORATING MYOTONIA | EISAI CO., LTD. (JP) | 2002-09-10 | — | — | US | disclosed |
| US-20020086999-A1 | Certain quinoline derivatives | EISAI CO., LTD. | 2002-07-04 | — | — | US | disclosed |
| US-20020019531-A1 | Indoles | EISAI CO., LTD. | 2002-02-14 | — | — | US | disclosed |
| EP-0976732-A1 | 1,4-SUBSTITUTED CYCLIC AMINE DERIVATIVES | Eisai Co., Ltd. (JP) | 2000-02-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019531-A1 | Indoles | INMT, MUSK, MB | HTR2A 209/4885DRD1 30/4885HTR2C 222/4885 |
| US-20020086999-A1 | Certain quinoline derivatives | CHRM1, CHRNA5, CHRNA4 | HTR2A 143/4885DRD1 30/4885HTR2C 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.