Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 6/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5163891 | 0.91 | HDAC6 (0.56) | CXCR4HDAC6MEN1KMT2ATP53 | |
| SCHEMBL3972856 | 0.81 | HDAC6 (0.55) | CXCR4HDAC6LTA4HPRMT5WDR77 | |
| SCHEMBL5127860 | 0.81 | ADRA1D (0.40) | MEN1KMT2ATP53CYP3A4CYP2D6 | |
| SCHEMBL2934330 | 0.79 | CXCR4 (0.69) | CXCR4HDAC6MEN1KMT2ATP53 | |
| SCHEMBL16083006 | 0.79 | CXCR4 (0.69) | CXCR4HDAC6MEN1KMT2ATP53 | |
| SCHEMBL6633759 | 0.78 | CXCR4 (0.46) | CXCR4HDAC6MEN1KMT2ATP53 | |
| SCHEMBL23125077 | 0.76 | HDAC6 (0.53) | CXCR4HDAC6MEN1KMT2ATP53 | |
| SCHEMBL3637783 | 0.76 | KMT2A (0.64) | CXCR4HDAC6MEN1KMT2ATP53 | |
| SCHEMBL13573606 | 0.76 | HDAC6 (0.49) | CXCR4HDAC6MEN1KMT2ATP53 | |
| SCHEMBL5519379 | 0.73 | CXCR4 (0.61) | CXCR4HDAC6MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190134037-A1 | INHIBITION OF ADAPTOR ASSOCIATED KINASE 1 FOR THE TREATMENT OF PAIN | LANTHORN THOMAS HERBERT (US) | 2019-05-09 | — | — | US | disclosed |
| US-7012075-B2 | Cathepsin cysteine protease inhibitors | MERCK & CO., INC. (US) | 2006-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190134037-A1 | INHIBITION OF ADAPTOR ASSOCIATED KINASE 1 FOR THE TREATMENT OF PAIN | AAK1, NCK1, DAPK1 | CXCR4 3421/4885HDAC6 1819/4885MEN1 4708/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.