SCHEMBL5163891

SCHEMBL5163891

[c]1ccc(CNCC2CCCCC2)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 2/20 0.56
HDAC3 O15379 1/20 0.51
HDAC4 P56524 1/20 0.51
HDAC1 Q13547 1/20 0.51
HDAC8 Q9BY41 1/20 0.51
HDAC5 Q9UQL6 1/20 0.51
RAB9A P51151 4/20 0.44
CXCR4 P61073 4/20 0.44
NPC1 O15118 3/20 0.44
SIGMAR1 Q99720 1/20 0.43
POLB P06746 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
CXCL12 P48061 1/20 0.40
ESRRA P11474 1/20 0.40
OPRM1 P35372 1/20 0.39
OPRD1 P41143 1/20 0.39
OPRK1 P41145 1/20 0.39
PRMT5 O14744 1/20 0.39
WDR77 Q9BQA1 1/20 0.39
LTA4H P09960 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5872370 0.91 CXCR4 (0.47) HDAC6HDAC3HDAC4HDAC1HDAC8
SCHEMBL3972856 0.90 HDAC6 (0.55) HDAC6HDAC3HDAC4HDAC1HDAC8
SCHEMBL7603669 0.81 CXCR4 (0.63) HDAC6HDAC3HDAC4HDAC1HDAC8
SCHEMBL10764797 0.81 CXCR4 (0.63) HDAC6HDAC3HDAC4HDAC1HDAC8
SCHEMBL6667025 0.80 HDAC6 (0.48) HDAC6HDAC3HDAC4HDAC1HDAC8
Hydrochloric Acid SCHEMBL31169762 0.80 CXCR4 (0.61) HDAC6HDAC3HDAC4HDAC1HDAC8
SCHEMBL3861590 0.80 HDAC6 (0.62) HDAC6HDAC3HDAC4HDAC1HDAC8
SCHEMBL10349210 0.79 CXCR4 (0.65) HDAC6HDAC3HDAC4HDAC1HDAC8
SCHEMBL8041968 0.79 SMN1; SMN2 (0.65) HDAC6HDAC3HDAC4HDAC1HDAC8
SCHEMBL18088394 0.79 RAB9A (0.60) HDAC6HDAC3HDAC4HDAC1HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1765803-A1 QUATERNARY SALT CCR2 ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 2007-03-28 EP disclosed
WO-2006012135-A1 QUATERNARY SALT CCR2 ANTAGONISTS JANSSEN PHARMACEUTICA, N. V. (BE) 2006-02-02 WO disclosed