Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT1 | P04628 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 11/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5124529 | 1.00 | WNT1 (0.38) | WNT1GSK3BDYRK1ACHRNA7KCNH2 | |
| SCHEMBL5126300 | 0.84 | CHRNA7 (0.39) | WNT1GSK3BDYRK1ACHRNA7KCNH2 | |
| SCHEMBL4047150 | 0.79 | HTR3A (0.41) | GFERLRRK2 | |
| SCHEMBL14307023 | 0.78 | GSK3A (0.43) | — | |
| SCHEMBL14276194 | 0.78 | GSK3A (0.43) | — | |
| SCHEMBL5125717 | 0.78 | HTR2C (0.38) | GFERPPARG | |
| SCHEMBL5117664 | 0.78 | HRH3 (0.41) | LRRK2 | |
| SCHEMBL4048516 | 0.77 | PPARG (0.46) | GFERPPARG | |
| SCHEMBL5117790 | 0.76 | HRH4 (0.39) | WNT1GSK3BDYRK1AGFER | |
| SCHEMBL5111493 | 0.75 | BRAF (0.51) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7078419-B2 | N-aryl-7-(pyridin-4yl-methyl-, oxy-, thio-or amino-)indole-2-carbonamide derivatives, e.g., 7-(2,6-Dimethyl-pyridin-4-yloxy)-1H-indole-2-carboxylic acid (5-tert-butyl-3-methanesulfonylamino-2-methoxy-phenyl)-amide; treating chronic inflammatory diseases and anticoagulant or fibrinolytic therapy | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2006-07-18 | — | — | US | disclosed |