Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7129737 | 0.94 | GAA (0.63) | GAAALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL7127595 | 0.91 | GAA (0.64) | GAAALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL3440531 | 0.86 | GAA (0.86) | GAAALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL20338317 | 0.85 | GAA (0.69) | GAAALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL5605504 | 0.84 | GAA (0.62) | GAAALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL20349175 | 0.84 | GAA (0.91) | GAAALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL21338467 | 0.84 | GAA (0.91) | GAAALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL3912798 | 0.84 | GAA (0.91) | GAAALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL30920954 | 0.84 | GAA (0.82) | GAAALDH1A1KDM4ETDP1SMN1; SMN2 | |
| SCHEMBL8719367 | 0.84 | HSD17B10 (0.56) | GAAALDH1A1KDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050171346-A1 | Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation | AVENTIS PHARMA S.A. (FR) | 2005-08-04 | — | — | US | claimed |
| US-7034022-B2 | Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation | AVENTIS PHARMA S. A. (FR) | 2006-04-25 | — | — | US | disclosed |
| US-20050171346-A1 | Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation | AVENTIS PHARMA S.A. (FR) | 2005-08-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171346-A1 | Hexahydropyridazine-3-carboxylic acid derivatives, pharmaceutical compositions containing same and methods of preparation | HEXD, CDK5, CHUK | GAA 353/4885ALDH1A1 454/4885KDM4E 2612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.