HEXD — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL587029	1.00	1/20
SCHEMBL587030	1.00	1/20
SCHEMBL2682089	1.00	1/20
SCHEMBL14643619	0.85	1/20
SCHEMBL586692	0.83	1/20
SCHEMBL14643410	0.81	1/20
SCHEMBL14644495	0.81	1/20
SCHEMBL14644817	0.81	1/20
SCHEMBL587230	0.79	1/20
SCHEMBL14643409	0.78	1/20
SCHEMBL14643408	0.75	1/20
SCHEMBL14643585	0.72	1/20
SCHEMBL582097	0.71	1/20
SCHEMBL14643591	0.71	1/20
SCHEMBL15930086	0.71	1/20
SCHEMBL13147496	0.69	1/20
SCHEMBL14644169	0.69	1/20
SCHEMBL14644195	0.69	1/20
SCHEMBL14644152	0.68	1/20
SCHEMBL14643623	0.68	1/20

Clinical trials — most relevant to HEXD by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Phase 4 Two Dose Level Study of Naglazyme(TM) (Galsulfase) in Infants With MPS VI	PHASE4	COMPLETED
Study of Intrathecal Idursulfase-IT Administered in Conjunction With Elaprase® in Pediatric Patients With Hunter Syndrome and Early Cognitive Impairment	PHASE2/PHASE3	COMPLETED
Intracerebroventricular Tralesinidase Alfa in Children With Mucopolysaccharidosis Type IIIB	PHASE3	NOT_YET_RECRUITING
Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Diseases	PHASE2/PHASE3	COMPLETED
Randomized, Controlled, Open-label, Multicenter, Safety and Efficacy Study of rhHNS Administration Via an IDDD in Pediatric Patients With Early Stage MPS IIIA Disease	PHASE2	COMPLETED
N-Acetyl-L-Leucine for GM2 Gangliosidosis (Tay-Sachs and Sandhoff Disease)	PHASE2	COMPLETED
Pyrimethamine as a Treatment for Late-Onset GM2-gangliosidosis (Tay-Sachs and Sandhoff Disease)	PHASE1/PHASE2	COMPLETED
Gene Therapy with Modified Autologous Hematopoietic Stem Cells for Patients with Mucopolysaccharidosis Type IIIA	PHASE1/PHASE2	ACTIVE_NOT_RECRUITING
Safety, Tolerability, Ascending Dose and Dose Frequency Study of rhHNS Via an IDDD in MPS IIIA Patients	PHASE1/PHASE2	COMPLETED
Open-Label Study of Efficacy and Safety of Recombinant Human N-acetylgalactosamine 4-sulfatase in Patients With MPS VI	PHASE2	COMPLETED
A Phase I Study of Pyrimethamine in Patients With GM2 Gangliosidosis	PHASE1	WITHDRAWN
A Study of the Tolerance, Safety, and Pharmacokinetics of GNR-055 in Healthy Volunteers	PHASE1	COMPLETED
Translational Potential of ex Vivo Gene Therapy in GM2 Gangliosidosis	nan	NOT_YET_RECRUITING
A Natural History of Late Onset Tay-Sachs Disease	nan	COMPLETED
Biomarker for Gangliosidosis: BioGM1/BioGM2 (BioGM1/GM2)	nan	WITHDRAWN
Biomarker for Hurler Disease (BioHurler)	nan	WITHDRAWN
The Natural History of Alpha-Mannosidosis	nan	COMPLETED
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis	nan	COMPLETED
Non-invasive Functional Assessment and Pathogenesis of Morquio A	nan	RECRUITING
Gene Therapy for Tay-Sachs Disease	nan	COMPLETED
Registry Gangliosidoses	nan	UNKNOWN
Study of the Prevalence of Acid Sphingomyelinase Deficiency/Niemann Pick AB and B Disease in Patients With Diffuse Interstitial Lung Disease	nan	NOT_YET_RECRUITING
Natural History of Morquio B and Late-Onset of GM1 Gangliosidosis	nan	UNKNOWN
Collection and Study of Cerebrospinal Fluid in Patients With Hunter Syndrome	nan	COMPLETED
Biomarker for Farber Disease (BioFarber)	nan	WITHDRAWN
Glycosylation in Patients With Galactosaemia	nan	COMPLETED
Natural History of Atypical Morquio A Disease	nan	COMPLETED
Characterization of the Patient Population With Galactosialidosis	nan	COMPLETED
Evaluation of Gastrointestinal Symptoms Following Chilean Native Beans Consumption	nan	UNKNOWN
A Study of Intrathecal Enzyme Therapy for Cognitive Decline in MPS I	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a HEXD binder may also engage these)

Protein	Name	Similarity
Q3U4H6	—	1.000	Q3U4H6 →
P19813	—	0.979	P19813 →
A6QNR0	—	0.979	A6QNR0 →
Q8SQG8	—	0.978	Q8SQG8 →
Q8VCZ9	—	0.978	Q8VCZ9 →
Q2V057	—	0.977	Q2V057 →
Q13724	—	0.977	Q13724 →
Q9UF12	—	0.977	Q9UF12 →
Q86U10	—	0.977	Q86U10 →
O35632	—	0.976	O35632 →
Q12891	—	0.976	Q12891 →
Q6RHW4	—	0.975	Q6RHW4 →
Q8SQG7	—	0.975	Q8SQG7 →
Q6P1J0	—	0.975	Q6P1J0 →
ITGB7	Integrin beta-7	0.975	landscape →
O88941	—	0.975	O88941 →
GAA	Lysosomal alpha-glucosidase	0.975	landscape →
P51840	—	0.975	P51840 →
Q5E985	—	0.974	Q5E985 →
Q8R123	—	0.974	Q8R123 →
P21836	—	0.973	P21836 →
TARS2	Threonine--tRNA ligase, mitochondrial	0.973	landscape →
TREH	Trehalase	0.973	landscape →
P23795	—	0.973	P23795 →
Q86TX2	—	0.972	Q86TX2 →
Q643R3	—	0.972	Q643R3 →
Q865R1	—	0.972	Q865R1 →
P37136	—	0.972	P37136 →
P10938	—	0.972	P10938 →
Q69ZQ1	—	0.972	Q69ZQ1 →