Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | ETV6 | P41212 | 4/20 | 0.43 |
| ▸ | PARP1 | P09874 | 5/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.38 |
| ▸ | ME2 | P23368 | 3/20 | 0.37 |
| ▸ | ME1 | P48163 | 3/20 | 0.37 |
| ▸ | ME3 | Q16798 | 3/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.37 |
| ▸ | HAMP | P81172 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872891 | 0.85 | FLT3 (0.46) | KDRETV6NTRK1FGFR1FGFR2 | |
| SCHEMBL5873090 | 0.81 | PLK4 (0.47) | KDRETV6NTRK1FGFR1FGFR2 | |
| SCHEMBL5872877 | 0.80 | LRRK2 (0.46) | KDRETV6NTRK1ACVR1 | |
| SCHEMBL5873162 | 0.79 | NTRK1 (0.55) | NTRK1ACVR1BMPR1A | |
| SCHEMBL6506307 | 0.79 | LRRK2 (0.53) | KDRETV6NTRK1FGFR1 | |
| SCHEMBL5873038 | 0.77 | NTRK1 (0.40) | NTRK1FGFR1FGFR2FGFR3ACVR1 | |
| SCHEMBL5873134 | 0.76 | PIM1 (0.42) | NTRK1FGFR1FGFR2FGFR3ACVR1 | |
| SCHEMBL5872887 | 0.74 | ACVR1 (0.44) | NTRK1FGFR1FGFR2FGFR3ACVR1 | |
| SCHEMBL5872977 | 0.72 | TNKS (0.46) | KDRETV6NTRK1FGFR1FGFR2 | |
| SCHEMBL5873036 | 0.70 | IDO1 (0.43) | FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050250823-A1 | Gyrase inhibitors | YAGER KRAIG | 2005-11-10 | — | — | US | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | KDR 4741/4885ETV6 3569/4885PARP1 211/4885 |
| US-20050250823-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | KDR 4741/4885ETV6 3569/4885PARP1 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.