Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | PYGM | P11217 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872944 | 0.85 | MAP2K1 (0.43) | MAP2K2MAP2K1MEN1KMT2ATDP1 | |
| SCHEMBL5872805 | 0.84 | ALDH1A1 (0.51) | ALDH1A1TSHRMEN1KMT2AHSD17B10 | |
| SCHEMBL5872833 | 0.84 | MEN1 (0.39) | MAP2K2MAP2K1ALDH1A1TSHRMEN1 | |
| SCHEMBL5872869 | 0.83 | MAP2K2 (0.41) | NPSR1MAP2K2MAP2K1ALDH1A1TSHR | |
| SCHEMBL5872892 | 0.81 | MAP2K2 (0.41) | MAP2K2MAP2K1ALDH1A1TSHRMEN1 | |
| SCHEMBL5872787 | 0.80 | MAP2K1 (0.42) | MAP2K2MAP2K1MEN1KMT2ATDP1 | |
| SCHEMBL5872922 | 0.80 | MAPT (0.41) | NPSR1MAP2K2MAP2K1ALDH1A1TSHR | |
| SCHEMBL5872972 | 0.80 | MAPT (0.41) | NPSR1MAP2K2MAP2K1ALDH1A1TSHR | |
| SCHEMBL5872855 | 0.80 | MAP2K1 (0.42) | MAP2K2MAP2K1ALDH1A1MEN1KMT2A | |
| SCHEMBL5872893 | 0.79 | KMT2A (0.40) | MAP2K2MAP2K1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001905-B2 | Substituted diarylamines as MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-02-21 | — | — | US | disclosed |
| US-20030225076-A1 | 5-Amide substituted diarylamines as mex inhibitors | BIWERSI CATHLIN (US) | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225076-A1 | 5-Amide substituted diarylamines as mex inhibitors | NRAS, MAPK6, MAPK12 | NPSR1 1867/4885MAP2K2 61/4885MAP2K1 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.