Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K2 | P36507 | 5/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 5/20 | 0.41 |
| ▸ | GPR6 | P46095 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5872787 | 0.88 | MAP2K1 (0.42) | MAP2K2MAP2K1IDO1MEN1KMT2A | |
| SCHEMBL5872944 | 0.86 | MAP2K1 (0.43) | MAP2K2MAP2K1IDO1MEN1KMT2A | |
| SCHEMBL5872805 | 0.85 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL5872819 | 0.85 | LMNA (0.48) | SMN1; SMN2ALDH1A1TSHRHTTMEN1 | |
| SCHEMBL5872837 | 0.85 | HCAR2 (0.49) | MAP2K2MAP2K1SMN1; SMN2TSHRHTT | |
| SCHEMBL5872955 | 0.83 | MAP2K1 (0.42) | MAP2K2MAP2K1ALDH1A1IDO1MEN1 | |
| SCHEMBL5872839 | 0.83 | MAP2K1 (0.42) | MAP2K2MAP2K1IDO1MEN1KMT2A | |
| SCHEMBL5872799 | 0.82 | MAP2K1 (0.49) | MAP2K2MAP2K1IDO1MEN1KMT2A | |
| SCHEMBL5872899 | 0.81 | NPSR1 (0.39) | MAP2K2MAP2K1GPR6ALDH1A1TSHR | |
| SCHEMBL5872945 | 0.81 | MAP2K1 (0.43) | MAP2K2MAP2K1IDO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7001905-B2 | Substituted diarylamines as MEK inhibitors | WARNER-LAMBERT COMPANY (US) | 2006-02-21 | — | — | US | disclosed |
| US-20030225076-A1 | 5-Amide substituted diarylamines as mex inhibitors | BIWERSI CATHLIN (US) | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225076-A1 | 5-Amide substituted diarylamines as mex inhibitors | NRAS, MAPK6, MAPK12 | MAP2K2 61/4885MAP2K1 71/4885GPR6 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.