Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.68 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.68 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 7/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.44 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 2/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | CLK3 | P49761 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5777277 | 0.87 | KDM4E (0.63) | IDO1LRRK2MAP2K4TTKKDM4E | |
| SCHEMBL30725847 | 0.83 | IDO1 (1.00) | IDO1LRRK2MAP2K4AXLTTK | |
| SCHEMBL12318034 | 0.83 | IDO1 (1.00) | IDO1LRRK2MAP2K4AXLTTK | |
| SCHEMBL5873036 | 0.82 | IDO1 (0.43) | IDO1LRRK2MAP2K4TTKKDM4E | |
| SCHEMBL5776631 | 0.81 | IDO1 (0.50) | IDO1LRRK2MAP2K4TTKKDM4E | |
| SCHEMBL5872808 | 0.80 | GAA (0.51) | IDO1MAP2K4KDM4EALDH1A1GAA | |
| SCHEMBL5768166 | 0.77 | IDO1 (0.66) | IDO1LRRK2AXLKDM4EALDH1A1 | |
| SCHEMBL5873219 | 0.76 | NAMPT (0.38) | IDO1LRRK2MAP2K4TTKKDM4E | |
| SCHEMBL11460952 | 0.76 | RARA (0.56) | KDM4EALDH1A1GAANPY5R | |
| SCHEMBL5873090 | 0.74 | PLK4 (0.47) | NTRK1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6984652-B2 | Gyrase inhibitors | WARNER-LAMBERT COMPANY LLC (US) | 2006-01-10 | — | — | US | disclosed |
| US-20050250823-A1 | Gyrase inhibitors | YAGER KRAIG | 2005-11-10 | — | — | US | disclosed |
| US-20050054697-A1 | Gyrase inhibitors | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054697-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | IDO1 651/4885LRRK2 2922/4885MAP2K4 2844/4885 |
| US-20050250823-A1 | Gyrase inhibitors | TOP1, TOP2A, TOP2B | IDO1 651/4885LRRK2 2922/4885MAP2K4 2844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.