Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.54 |
| ▸ | HTR3B | O95264 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | THPO | P40225 | 1/20 | 0.54 |
| ▸ | HTR3A | P46098 | 1/20 | 0.54 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.54 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 6/20 | 0.43 |
| ▸ | RHOA | P61586 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6558013 | 0.94 | ALDH1A1 (0.49) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL3540666 | 0.80 | ALDH1A1 (0.60) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL4846555 | 0.80 | ALDH1A1 (0.51) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL4848007 | 0.79 | ALDH1A1 (0.53) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL5873493 | 0.78 | MCHR1 (0.46) | ALDH1A1SLC6A4HTR3ALMNAMCHR1 | |
| SCHEMBL5832121 | 0.76 | ALDH1A1 (0.59) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL3386080 | 0.76 | ALDH1A1 (0.58) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL5175267 | 0.75 | ALDH1A1 (0.52) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL3541348 | 0.75 | ALDH1A1 (0.64) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 | |
| SCHEMBL3382640 | 0.73 | ALDH1A1 (0.61) | ALDH1A1HTR3EHTR3BCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7084156-B2 | 2-Aminoquinoline compounds | MERCK & CO., INC. (US) | 2006-08-01 | — | — | US | disclosed |
| US-20050026915-A1 | 2-Aminoquinoline compounds | MERCK SHARP & DOHME CORP. | 2005-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026915-A1 | 2-Aminoquinoline compounds | MCHR1, MCHR2, MC5R | ALDH1A1 460/4885HTR3E 46/4885HTR3B 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.