Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dichloroacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lactic Acid SCHEMBL1832719 | 0.82 | TP53 (0.69) | TP53ALDH1A1TSHRSLC7A5 | |
| Bicarbonate SCHEMBL1832823 | 0.82 | TP53 (0.47) | LMNATP53ALDH1A1TSHRSLC7A5 | |
| Dichloroacetic Acid SCHEMBL9560991 | 0.82 | LMNA (0.71) | LMNATP53ALDH1A1TSHRSLC7A5 | |
| Cadaverine Tartrate SCHEMBL1835488 | 0.80 | TSHR (0.59) | LMNATP53ALDH1A1TSHRSLC7A5 | |
| Methylmalonic Acid SCHEMBL5874135 | 0.80 | TP53 (0.47) | TP53TSHRSLC7A5 | |
| Dichloroacetic Acid SCHEMBL316728 | 0.80 | LMNA (0.59) | LMNATP53ALDH1A1SLC7A5 | |
| Dichloroacetic Acid SCHEMBL28479696 | 0.79 | LMNA (0.67) | LMNATP53ALDH1A1TSHRSLC7A5 | |
| Acetic Acid SCHEMBL1831396 | 0.79 | FFAR3 (0.47) | TP53ALDH1A1TSHR | |
| Oxalic Acid SCHEMBL1834268 | 0.79 | TP53 (0.44) | LMNATP53ALDH1A1TSHR | |
| Dichloroacetic Acid SCHEMBL5874749 | 0.78 | LMNA (0.56) | LMNATP53ALDH1A1TSHRSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |