Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | KDM5A | P29375 | 4/20 | 0.45 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.36 |
| ▸ | ICMT | O60725 | 1/20 | 0.36 |
| ▸ | ALB | P02768 | 1/20 | 0.36 |
| ▸ | TET3 | O43151 | 1/20 | 0.36 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL5874416 | 1.00 | SMN1; SMN2 (0.58) | SMN1; SMN2GPR84FFAR1KDM5APHF8 | |
| Malic Acid SCHEMBL1131786 | 0.93 | SMN1; SMN2 (0.50) | SMN1; SMN2GPR84FFAR1KDM5APHF8 | |
| Malic Acid SCHEMBL5875321 | 0.88 | SMN1; SMN2 (0.62) | SMN1; SMN2GPR84FFAR1KDM4CTET2 | |
| Malic Acid SCHEMBL5875327 | 0.88 | SMN1; SMN2 (0.62) | SMN1; SMN2GPR84FFAR1KDM4CTET2 | |
| Malic Acid SCHEMBL1131789 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2GPR84FFAR1TET2TET3 | |
| Malic Acid SCHEMBL20394029 | 0.81 | SMN1; SMN2 (0.79) | SMN1; SMN2GPR84FFAR1KDM4CTET2 | |
| Malic Acid SCHEMBL11772086 | 0.80 | DNM1 (0.52) | SMN1; SMN2GPR84FFAR1KDM5APHF8 | |
| Malic Acid SCHEMBL11772074 | 0.80 | DNM1 (0.52) | SMN1; SMN2GPR84FFAR1KDM5APHF8 | |
| Malic Acid SCHEMBL27725825 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2GPR84FFAR1 | |
| Lactic Acid SCHEMBL23361679 | 0.79 | TP53 (0.50) | GPR84FFAR1KDM5APHF8KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119684381-A | Crystalline forms of nicotinamide riboside furanoside salts and nutritional supplements and pharmaceutical compositions containing same | 生物合成股份公司 | 2025-03-25 | — | — | CN | disclosed |
| CN-119462782-A | Method for producing nicotinamide riboside salts, nicotinamide riboside salts per se and use thereof | 生物合成股份公司 | 2025-02-18 | — | — | CN | disclosed |
| CN-114423771-A | Method for producing nicotinamide ribofuranoside salts, nicotinamide ribofuranoside salts themselves and use thereof | 生物合成股份公司 | 2022-04-29 | — | — | CN | disclosed |
| CN-101745290-B | Mixed ionic liquid solution special for absorbing SO2 gas and preparation method thereof | JIANGSU BEST ENVIRONMENT PROT CO LTD | 2012-08-22 | — | — | CN | disclosed |
| CN-101745290-A | Mixed ionic liquid solution special for absorbing SO2 gas and preparation method thereof | JIANGSU BEST ENVIRONMENT PROT | 2010-06-23 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |