Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDRD2HTR1BHTR1DHTR1F
The experimentally established mechanism targets of Malic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.52 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | KDM4A | O75164 | 5/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.40 |
| ▸ | KDM5A | P29375 | 1/20 | 0.40 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.40 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Malic Acid SCHEMBL11772074 | 1.00 | DNM1 (0.52) | DNM1SMN1; SMN2GPR84FFAR1KDM4A | |
| Malic Acid SCHEMBL1888155 | 0.88 | GPR84 (0.44) | DNM1SMN1; SMN2GPR84FFAR1 | |
| Behenic Acid SCHEMBL7783098 | 0.85 | GPR84 (0.46) | GPR84FFAR1 | |
| Malic Acid SCHEMBL27655462 | 0.85 | SMN1; SMN2 (0.60) | SMN1; SMN2GPR84FFAR1KDM4AKDM4C | |
| Malic Acid SCHEMBL27783805 | 0.84 | GPR84 (0.46) | SMN1; SMN2GPR84FFAR1KDM4CKDM5A | |
| Malic Acid SCHEMBL4851298 | 0.83 | DNM1 (0.72) | DNM1 | |
| Behenic Acid SCHEMBL7783097 | 0.82 | GPR84 (0.46) | GPR84FFAR1 | |
| Lactic Acid SCHEMBL23174633 | 0.82 | DNM1 (0.60) | DNM1GPR84FFAR1 | |
| Lactic Acid SCHEMBL29600390 | 0.82 | DNM1 (0.60) | DNM1GPR84FFAR1 | |
| Lactic Acid SCHEMBL5934076 | 0.82 | DNM1 (0.60) | DNM1GPR84FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3954846-A | New quaternary ammonium salts of malic acid and their application in cosmetics | AGENCE NATIONALE DE VALORIZATION DE LA RECHERCHE (ANVAR) (FR) | 1976-05-04 | — | — | US | disclosed |