Itaconate

Itaconate

SCHEMBL5874665

C=C(CC(=O)O)C(=O)O.CC[N+](CC)(CC)CC

nearest known ligand 0.68

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 1/20 0.56
HSD17B10 Q99714 1/20 0.56
TSHR P16473 1/20 0.36
NFKB1 P19838 1/20 0.36
KCNA1 Q09470 1/20 0.36
LDHA P00338 1/20 0.35
SRR Q9GZT4 1/20 0.35
KDM4E B2RXH2 1/20 0.35
PMP22 Q01453 1/20 0.35
ATM Q13315 1/20 0.35
TET2 Q6N021 4/20 0.34
FFAR3 O14843 1/20 0.33
TET3 O43151 1/20 0.32
TET1 Q8NFU7 1/20 0.32
GRIK1 P39086 1/20 0.31
GRIK2 Q13002 1/20 0.31
GRM1 Q13255 1/20 0.31
GRM2 Q14416 1/20 0.31
ALDH1A1 P00352 1/20 0.31
ALDH2 P05091 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Itaconate SCHEMBL6551910 1.00 ALOX15 (0.56) ALOX15HSD17B10TSHRNFKB1KCNA1
Itaconate SCHEMBL5874668 0.84 ALOX15 (0.39) ALOX15HSD17B10TSHRNFKB1KCNA1
Itaconate SCHEMBL106953 0.83 ALOX15 (0.62) ALOX15HSD17B10TSHRLDHASRR
Itaconate SCHEMBL904587 0.83 ALOX15 (0.62) ALOX15HSD17B10TSHRLDHASRR
Itaconate SCHEMBL876139 0.83 ALOX15 (0.62) ALOX15HSD17B10TSHRLDHASRR
Itaconate SCHEMBL107587 0.83 ALOX15 (0.62) ALOX15HSD17B10TSHRLDHASRR
Itaconate SCHEMBL5447650 0.83 ALOX15 (0.68) ALOX15HSD17B10TSHRLDHASRR
Tetrapropylammonium SCHEMBL108074 0.83 ALOX15 (0.52) ALOX15HSD17B10TSHRTET2ALDH1A1
Itaconate SCHEMBL29886131 0.83
Itaconate SCHEMBL286967 0.83 ALOX15 (0.75) ALOX15HSD17B10TSHRLDHASRR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7128976-B2 Composition for film formation, method of film formation, and silica-based film JSR CORPORATION (JP) 2006-10-31 US disclosed
US-20030091838-A1 Composition for film formation, method of film formation, and silica-based film JSR CORPORATION (JP) 2003-05-15 US disclosed
US-4734821-A AMMONIUM SALT OF CARBOXYLIC ACID ASAHI GLASS COMPANY LTD. (JP) 1988-03-29 US disclosed