Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SLC13A5 | Q86YT5 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL5874858 | 1.00 | ALDH1A1 (0.53) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 | |
| Citric Acid SCHEMBL28296321 | 0.97 | ALDH1A1 (0.50) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 | |
| Citric Acid SCHEMBL28125420 | 0.88 | ALDH1A1 (0.53) | ALDH1A1SLC13A5LMNAKDM4EMEN1 | |
| Quinoline SCHEMBL28028904 | 0.83 | ALDH1A1 (0.65) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| Benzylic Acid SCHEMBL27306203 | 0.81 | ALDH1A1 (0.57) | ALDH1A1LMNAKDM4ECYP2D6MEN1 | |
| Citric Acid SCHEMBL2517794 | 0.80 | SLC13A5 (0.49) | ALDH1A1SLC13A5LMNAKDM4ECYP1A2 | |
| Quinoline SCHEMBL4733766 | 0.80 | ALDH1A1 (0.65) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| Quinoline SCHEMBL5874815 | 0.80 | ALDH1A1 (0.65) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| Quinoline SCHEMBL5874587 | 0.80 | ALDH1A1 (0.65) | ALDH1A1LMNAKDM4EMEN1KMT2A | |
| Quinoline SCHEMBL5874979 | 0.80 | ALDH1A1 (0.65) | ALDH1A1LMNAKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |