Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Quinoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | PRNP | P04156 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL5874815 | 1.00 | ALDH1A1 (0.65) | ALDH1A1PRNPRXFP1POLBMAPK10 | |
| Adipic Acid SCHEMBL5875328 | 0.93 | ALDH1A1 (0.61) | ALDH1A1PRNPRXFP1MAPK10NPSR1 | |
| Adipic Acid SCHEMBL5875340 | 0.93 | ALDH1A1 (0.61) | ALDH1A1PRNPRXFP1MAPK10NPSR1 | |
| Quinoline SCHEMBL5874797 | 0.93 | ALDH1A1 (0.61) | ALDH1A1PRNPRXFP1POLBMAPK10 | |
| Quinoline SCHEMBL5874806 | 0.93 | ALDH1A1 (0.61) | ALDH1A1PRNPRXFP1POLBMAPK10 | |
| Adipic Acid SCHEMBL28641209 | 0.93 | ALDH1A1 (0.61) | ALDH1A1PRNPRXFP1MAPK10NPSR1 | |
| Sebacic Acid SCHEMBL5875076 | 0.91 | ALDH1A1 (0.59) | ALDH1A1PRNPRXFP1MAPK10NPSR1 | |
| Quinoline SCHEMBL28689937 | 0.91 | ALDH1A1 (0.59) | ALDH1A1PRNPRXFP1POLBMAPK10 | |
| Sebacic Acid SCHEMBL5875085 | 0.91 | ALDH1A1 (0.59) | ALDH1A1PRNPRXFP1MAPK10NPSR1 | |
| Quinoline SCHEMBL5874503 | 0.90 | ALDH1A1 (0.57) | ALDH1A1PRNPRXFP1POLBMAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106318536-B | A kind of hydrodynamic lubrication fluid composition and preparation method thereof | 中国石油化工股份有限公司 | 2019-06-14 | — | — | CN | claimed |
| CN-106318520-B | A kind of lubricant oil composite and preparation method thereof | 中国石油化工股份有限公司 | 2019-06-14 | — | — | CN | claimed |
| CN-106318552-B | A kind of hydrodynamic lubrication fluid composition and preparation method thereof | 中国石油化工股份有限公司 | 2019-02-01 | — | — | CN | claimed |
| CN-1035823-C | Process for preparing latent catalysts for curing epoxy resins | DOW CHEMICAL CO (US) | 1997-09-10 | — | — | CN | claimed |
| CN-1056699-A | Latent catalysts and cure-inhibited epoxy resin compositions and laminates made therefrom | DOW CHEMICAL CO (US) | 1991-12-04 | — | — | CN | claimed |
| WO-2008067399-A2 | CONTROLLED-RELEASE MULTI-LAYER FORMULATION OF PIPERAZINE-PIPERIDINE ANTAGONISTS AND AGONISTS OF THE 5-TH1A RECEPTOR HAVING ENHANCED INTESTINAL DISSOLUTION | WYETH (US) | 2008-06-05 | — | — | WO | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |
| CN-1050617-C | Latent catalysts, cure-inhibited epxoy resin compositions and laminates prepared therefrom | DOW CHEMICAL CO (US) | 2000-03-22 | — | — | CN | disclosed |
| CN-1050618-C | Latent Catalysts, Cure-inhibited epxoy resin compositions and laminates prepared therefrom | DOW CHEMICAL CO (US) | 2000-03-22 | — | — | CN | disclosed |
| CN-1035823-C | Process for preparing latent catalysts for curing epoxy resins | DOW CHEMICAL CO (US) | 1997-09-10 | — | — | CN | disclosed |
| CN-1118794-A | Latent Catalysts, Cure-inhibited epxoy resin compositions and laminates prepared therefrom | DOW CHEMICAL CO (US) | 1996-03-20 | — | — | CN | disclosed |
| CN-1118793-A | Latent catalysts, cure-inhibited epxoy resin compositions and laminates prepared therefrom | DOW CHEMICAL CO (US) | 1996-03-20 | — | — | CN | disclosed |
| CN-1056699-A | Latent catalysts and cure-inhibited epoxy resin compositions and laminates made therefrom | DOW CHEMICAL CO (US) | 1991-12-04 | — | — | CN | disclosed |
| CN-85105798-A | Octahydro- azoles is the preparation method of [4,5-g] quinoline also | — | 1987-01-28 | — | — | CN | disclosed |
| CN-85101547-A | The preparation method and its usage of novel octahydro thiazole [4,5-g] and quinoline compound | — | 1987-01-24 | — | — | CN | disclosed |