Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Methylmalonic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | GABRE | P78334 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.36 |
| ▸ | CPN1 | P15169 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylmalonic Acid SCHEMBL5874885 | 1.00 | TP53 (0.40) | TP53GABRPGABRDGABRA1TSHR | |
| Methylmalonic Acid SCHEMBL5874764 | 0.87 | ALDH1A1 (0.45) | TP53GABRPGABRDGABRA1TSHR | |
| Methylmalonic Acid SCHEMBL5874773 | 0.87 | ALDH1A1 (0.45) | TP53GABRPGABRDGABRA1TSHR | |
| Methylmalonic Acid SCHEMBL11452201 | 0.83 | MEN1 (0.48) | TP53GABRPGABRDGABRA1TSHR | |
| Piperazine SCHEMBL7553577 | 0.82 | TP53 (0.65) | TP53GABRPGABRDGABRA1TSHR | |
| Piperazine SCHEMBL7554819 | 0.82 | TP53 (0.65) | TP53GABRPGABRDGABRA1TSHR | |
| Aziridine SCHEMBL11412834 | 0.81 | — | — | |
| Methylmalonic Acid SCHEMBL27881917 | 0.80 | TP53 (0.57) | TP53TSHRSLC7A5CYP1A2 | |
| Methylmalonic Acid SCHEMBL27766 | 0.80 | — | — | |
| Piperazine SCHEMBL1415150 | 0.80 | SLC7A5 (0.43) | TP53GABRPGABRDGABRA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |