Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glutarate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | TSHR | P16473 | 4/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.46 |
| ▸ | GABRP | O00591 | 1/20 | 0.46 |
| ▸ | GABRD | O14764 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.46 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.46 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.46 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.46 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutarate SCHEMBL5875165 | 1.00 | SLC22A6 (0.65) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Adipic Acid SCHEMBL31163175 | 0.94 | LMNA (0.65) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Adipic Acid SCHEMBL5875324 | 0.94 | LMNA (0.65) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Adipic Acid SCHEMBL1642955 | 0.94 | LMNA (0.65) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Piperazine SCHEMBL8581904 | 0.92 | TSHR (0.67) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Sebacic Acid SCHEMBL5875109 | 0.92 | TSHR (0.67) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Sebacic Acid SCHEMBL5875095 | 0.92 | TSHR (0.67) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Adipic Acid SCHEMBL9949118 | 0.88 | LMNA (0.65) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Piperazine SCHEMBL27772877 | 0.88 | EGLN1 (0.50) | SLC22A6LMNATSHRNFKB1PMP22 | |
| Glutarate SCHEMBL31031783 | 0.88 | SLC22A6 (0.50) | SLC22A6LMNATSHRNFKB1PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |