Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | EYA2 | O00167 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL5875232 | 1.00 | CA12 (0.50) | CA12CA9CA2CA1TSHR | |
| Oxalic Acid SCHEMBL5874925 | 0.90 | CA12 (0.48) | CA12CA9CA2CA1TSHR | |
| Acetic Acid SCHEMBL5571031 | 0.90 | CA12 (0.48) | CA12CA9CA2CA1TSHR | |
| Oxalic Acid SCHEMBL5874919 | 0.90 | CA12 (0.48) | CA12CA9CA2CA1TSHR | |
| Hydrogen Peroxide SCHEMBL139782 | 0.89 | CA12 (0.43) | CA12CA9CA2CA1TSHR | |
| Hydrogen Peroxide SCHEMBL139780 | 0.89 | CA12 (0.43) | CA12CA9CA2CA1TSHR | |
| Propionic Acid SCHEMBL3410973 | 0.88 | FFAR3 (0.59) | CA12CA9CA2CA1TSHR | |
| Bicarbonate SCHEMBL29110485 | 0.87 | CA12 (0.41) | CA12CA9CA2CA1TSHR | |
| Succinic Acid SCHEMBL5874689 | 0.85 | FFAR3 (0.55) | TSHRFFAR3HDAC3HDAC1HDAC2 | |
| Glycolic Acid SCHEMBL21145147 | 0.85 | CA12 (0.44) | CA12CA9CA2CA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117303615-A | Treatment process of high-mineralization oily sewage | 中国石油天然气股份有限公司 | 2023-12-29 | — | — | CN | disclosed |
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |