Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM5A | P29375 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.42 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL5875268 | 1.00 | ALDH1A1 (0.58) | ALDH1A1KDM4ELMNACYP1A2CYP2D6 | |
| Citric Acid SCHEMBL1131810 | 0.93 | KDM4E (0.50) | ALDH1A1KDM4ELMNACYP1A2CYP2D6 | |
| Citric Acid SCHEMBL22556290 | 0.93 | ALDH1A1 (0.54) | ALDH1A1KDM4ELMNACYP1A2CYP2D6 | |
| Citric Acid SCHEMBL5874663 | 0.88 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNACYP1A2CYP2D6 | |
| Citric Acid SCHEMBL5874658 | 0.88 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNACYP1A2CYP2D6 | |
| Citric Acid SCHEMBL9431044 | 0.86 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNACYP1A2CYP2D6 | |
| Citric Acid SCHEMBL28044779 | 0.86 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNACYP1A2CYP2D6 | |
| Citric Acid SCHEMBL8917064 | 0.84 | ALDH1A1 (0.68) | ALDH1A1KDM4ELMNACYP1A2CYP2D6 | |
| Citric Acid SCHEMBL875432 | 0.84 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2AALOX15TSHR | |
| Citric Acid SCHEMBL10687560 | 0.84 | ALDH1A1 (0.68) | ALDH1A1MEN1KMT2AALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7128976-B2 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2006-10-31 | — | — | US | disclosed |
| US-20030091838-A1 | Composition for film formation, method of film formation, and silica-based film | JSR CORPORATION (JP) | 2003-05-15 | — | — | US | disclosed |