Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL27712182 | 0.92 | CHRM1 (0.44) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL2382234 | 0.89 | — | — | |
| SCHEMBL29157267 | 0.89 | THRB (0.56) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL2381476 | 0.89 | — | — | |
| SCHEMBL62155 | 0.89 | — | — | |
| Glycerin SCHEMBL3252402 | 0.86 | LMNA (0.56) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| SCHEMBL31303531 | 0.86 | — | — | |
| Hydrochloric Acid SCHEMBL21682461 | 0.86 | — | — | |
| Alcohol SCHEMBL15477222 | 0.86 | THRB (0.53) | CHRM1AKR1A1CHRM3HTR2AHTR2C | |
| Ammonia Solution, Strong SCHEMBL8212958 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113429259-B | Fluorine-containing compound and application thereof | 中国科学院上海有机化学研究所 | 2023-03-24 | — | — | CN | claimed |
| CN-113429259-A | Fluorine-containing compound and application thereof | 中国科学院上海有机化学研究所 | 2021-09-24 | — | — | CN | claimed |
| US-7049387-B2 | Cure accelerator system for phenolic resins | GEORGIA-PACIFIC RESINS, INC. (US) | 2006-05-23 | — | — | US | claimed |
| US-20030071393-A1 | Cure accelerator system for phenolic resins | JPMORGAN CHASE BANK, N.A. | 2003-04-17 | — | — | US | claimed |
| EP-1302489-A1 | Cure accelerator system for phenolic resins | GEORGIA-PACIFIC CORPORATION (US) | 2003-04-16 | — | — | EP | claimed |
| EP-0469785-B1 | Retarders for curing/hardening resole resins | BORDEN INC (US) | 1995-01-11 | — | — | EP | claimed |
| US-5096983-A | Magnesium oxide and and ester as hardeners, retarder to inhibit hardening | BORDEN, INC. (US) | 1992-03-17 | — | — | US | claimed |
| EP-0469785-A2 | Retarders for curing/hardening resole resins | Borden, Inc. (US) | 1992-02-05 | — | — | EP | claimed |
| CN-113429259-B | Fluorine-containing compound and application thereof | 中国科学院上海有机化学研究所 | 2023-03-24 | — | — | CN | disclosed |
| US-8865287-B2 | Rapid curing aldehyde resin-polyisocyanate composition and method for producing hybrid polymer | RAMBUS INC. | 2014-10-21 | — | — | US | disclosed |
| EP-2788108-A1 | MEMBRANE, WATER TREATMENT SYSTEM, AND METHOD OF MAKING | General Electric Company (US) | 2014-10-15 | — | — | EP | disclosed |
| US-8616380-B2 | Reverse osmosis composite membranes for boron removal | GENERAL ELECTRIC COMPANY (US) | 2013-12-31 | — | — | US | disclosed |
| US-8580341-B2 | Method of making composite membrane | GENERAL ELECTRIC COMPANY (US) | 2013-11-12 | — | — | US | disclosed |
| US-20130146530-A1 | MEMBRANE, WATER TREATMENT SYSTEM, AND METHOD OF MAKING | GENERAL ELECTRIC COMPANY (US) | 2013-06-13 | — | — | US | disclosed |
| US-5082876-A | Alkaline phenolic resin | BORDEN, INC. (US) | 1992-01-21 | — | — | US | disclosed |
| US-5043412-A | Blend of phenol-formaldehyde novolak and resole resins, and curing agent | BORDEN, INC. (US) | 1991-08-27 | — | — | US | disclosed |
| US-4961795-A | USING ALKALINE PHENOL-FORMALDEHYDE RESIN BINDER, CURING AGENT,AN MODIFIER | BORDEN, INC. (US) | 1990-10-09 | — | — | US | disclosed |
| US-4862948-A | Phenolic resin adhesive pastes, assemblies prepared therefrom, and processes for preparing cast metal articles using these pastes | BORDEN, INC. (US) | 1989-09-05 | — | — | US | disclosed |
| EP-0330307-A2 | Phenolic resin adhesive pastes, assemblies prepared therefrom, and processes for preparing cast metal articles using these pastes | ACME RESIN CORPORATION (US) | 1989-08-30 | — | — | EP | disclosed |
| EP-0259042-A2 | Process for bonding lignocellulosic material | Borden, Inc. (US) | 1988-03-09 | — | — | EP | disclosed |