Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | GHSR | Q92847 | 3/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877219 | 1.00 | LMNA (0.39) | LMNACYP1A1CYP1A2NFE2L2CYP1B1 | |
| SCHEMBL7487743 | 0.95 | LMNA (0.37) | LMNACYP1A1CYP1A2NFE2L2CYP1B1 | |
| SCHEMBL7487746 | 0.95 | LMNA (0.37) | LMNACYP1A1CYP1A2NFE2L2CYP1B1 | |
| SCHEMBL5878481 | 0.94 | MAPT (0.40) | LMNAPDE5APDE4APDE4BPDE4C | |
| SCHEMBL5878477 | 0.94 | MAPT (0.40) | LMNAPDE5APDE4APDE4BPDE4C | |
| SCHEMBL5877273 | 0.94 | LMNA (0.46) | LMNAMEN1KMT2ATLR9MAPT | |
| SCHEMBL5877277 | 0.94 | LMNA (0.46) | LMNAMEN1KMT2ATLR9MAPT | |
| SCHEMBL5878166 | 0.89 | KDM4E (0.45) | LMNAGHSRCYP3A4DPP4MEN1 | |
| SCHEMBL5878162 | 0.89 | KDM4E (0.45) | LMNAGHSRCYP3A4DPP4MEN1 | |
| SCHEMBL5878051 | 0.88 | MEN1 (0.38) | LMNACYP1A1CYP1A2NFE2L2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |