Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5877277 | 1.00 | LMNA (0.46) | LMNATP53GAAMEN1KMT2A | |
| SCHEMBL5877223 | 0.94 | LMNA (0.39) | LMNATP53MEN1KMT2ATLR9 | |
| SCHEMBL5877219 | 0.94 | LMNA (0.39) | LMNATP53MEN1KMT2ATLR9 | |
| SCHEMBL7487743 | 0.91 | LMNA (0.37) | LMNAMEN1KMT2ATLR9ALDH1A1 | |
| SCHEMBL7487746 | 0.91 | LMNA (0.37) | LMNAMEN1KMT2ATLR9ALDH1A1 | |
| SCHEMBL5878481 | 0.90 | MAPT (0.40) | LMNATP53MEN1KMT2AMAPT | |
| SCHEMBL5878477 | 0.90 | MAPT (0.40) | LMNATP53MEN1KMT2AMAPT | |
| SCHEMBL5878051 | 0.89 | MEN1 (0.38) | LMNATP53GAAMEN1KMT2A | |
| SCHEMBL5878047 | 0.88 | ALDH1A1 (0.45) | LMNAMEN1KMT2ATLR9ALDH1A1 | |
| SCHEMBL5878041 | 0.88 | ALDH1A1 (0.45) | LMNAMEN1KMT2ATLR9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7060706-B1 | Quinazolinones | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2006-06-13 | — | — | US | disclosed |
| EP-1216233-A1 | QUINAZOLINONES | MERCK PATENT GmbH (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001023364-A1 | QUINAZOLINONES | MERCK PATENT GMBH (DE) | 2001-04-05 | — | — | WO | disclosed |